So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Thompson, Alison; Gao, Susan; Modzelewska, Gosia; Hughes, David S.; Patrick, Brian; Dolphin, David researched the compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate( cas:2199-44-2 ).Computed Properties of C9H13NO2.They published the article 《x-ray Crystallographic and 13C NMR Investigations of the Effects of Electron-Withdrawing Groups on a Series of Pyrroles》 about this compound( cas:2199-44-2 ) in Organic Letters. Keywords: crystallog carbon NMR electron withdrawing group pyrrole derivative. We’ll tell you more about this compound (cas:2199-44-2).
Pyrroles substituted with various electron-withdrawing groups (EWGs) on the N atom were synthesized and full characterization including x-ray crystal structures obtained. Anal. of 13C chem. shifts and x-ray crystal structures reveals that a trend between decreased aromaticity and the strength of the EWG exists. Exptl. results regarding alternative mechanisms of nucleophilic substitution reactions can thus be rationalized.
In some applications, this compound(2199-44-2)Computed Properties of C9H13NO2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com