The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate( cas:2199-44-2 ) is researched.HPLC of Formula: 2199-44-2.Vom, Amelia; Headey, Stephen; Wang, Geqing; Capuano, Ben; Yuriev, Elizabeth; Scanlon, Martin J.; Simpson, Jamie S. published the article 《Detection and Prevention of Aggregation-based False Positives in STD-NMR-based Fragment Screening》 about this compound( cas:2199-44-2 ) in Australian Journal of Chemistry. Keywords: fragment screening saturation transfer difference NMR ketopantoate reductase. Let’s learn more about this compound (cas:2199-44-2).
Aggregation of small organic compounds is a problem encountered in a variety of assay screening formats where it often results in detection of false positives. A saturation transfer difference-NMR-detected screen of a com. available fragment library, followed by biochem. assay, identified several inhibitors of the enzyme ketopantoate reductase. These inhibitors were subsequently revealed to be aggregation-based false positives. Modification of the fragment screen by addition of detergent in the saturation transfer difference-NMR experiments allowed an assay format to be developed that resulted in the identification of genuine hit mols. suitable for further development.
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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com