The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Chloro-7-nitro-1H-benzo[d]imidazole(SMILESS: O=[N+](C1=C2NC(Cl)=NC2=CC=C1)[O-],cas:15965-55-6) is researched.SDS of cas: 7661-33-8. The article 《Synthesis and antitrichomonal activity of azinium (azolium) 4-nitrobenzimidazolate betaines and their derivatives》 in relation to this compound, is published in European Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:15965-55-6).
Among the many attractive types of heterocyclic betaines, the inner salts of azinium azolates and azolium azolates are few and scattered. The antiprotozoal activity (in vitro) against Trichomonas vaginalis of a variety of mesomeric betaines of pyridinium azolates, their N-azolylpyridinium salts, and N-5-nitrobenzimidazol-2-ylpyridinium derivatives, e.g. 1-(5-nitro-1H-benzimidazol-2-yl)-2,4,6-triphenylpyridinium salts was reported. In the present study, 1-(4-nitro-1H-benzimidazol-2-yl)pyridinium salts were prepared and tested against T. vaginalis in vitro and in vivo.
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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com