An article Highly efficient catalyst-free domino conjugate addition, decarboxylation and esterification/amidation of coumarin carboxylic acid/esters with pyrazolones: a green chemistry approach WOS:000530352000059 published article about FLUORESCENCE CHEMOSENSORS; DIRECT AMIDATION; FACILE SYNTHESIS; RAPID SYNTHESIS; DERIVATIVES; INHIBITORS; MCI-186; ACIDS; DISCOVERY; ISCHEMIA in [Lakshmi, Shanta Raj; Singh, Vipin; Chowhan, L. Raju] Cent Univ Gujarat, Ctr Appl Chem, Sect 30, Gandhinagar 382030, India in 2020.0, Cited 61.0. SDS of cas: 94-41-7. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7
Tandem conjugate addition, decarboxylation and esterification/amidation of coumarin 3-carboxylic acid derivatives with pyrazolones have been developed. The reactions were performed with coumarin 3-carboxylic acid/esters and pyrazolone in alcohol as a solvent to afford the corresponding pyrazolyl 2-hydroxy phenylpropionate derivatives. Amines and green solvents were employed for amidation in the addition reaction. The methodology has advantages such as excellent yields, a broad substrate scope, catalyst-free, easy purification by simple filtration without any workup, mild conditions and does not require any organic solvents, ligands, base or any additives. This is a green and general synthetic protocol, which could be applicable for the synthesis of substituted pyrazolyl phenyl propionate/amide derivatives. This approach demonstrates the importance of the coumarin 3-carboxylic acid/ester core structure for Michael addition.
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com