COA of Formula: C15H12O. Recently I am researching about MUSHROOM TYROSINASE; KOJIC ACID; EQUILIBRIUM-CONSTANTS; DERIVATIVES; PROGRAM; MECHANISM; DESIGN, Saw an article supported by the Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LY17B020001]; School of Food Science and Biotechnology, Zhejiang Gongshang University. Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Singh, LR; Chen, YL; Xie, YY; Xia, W; Gong, XW; Hider, RC; Zhou, T. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone
In an attempt to synthesise new tyrosinase inhibitors, we designed and synthesised a series of chalcone-hydroxypyridinone hybrids as potential tyrosinase inhibitors adopting strategic modifications of kojic acid. All the newly synthesised compounds were characterised by NMR and mass spectrometry. Initial screening of the target compounds demonstrated that compounds1a,1d, and1nhad relatively strong inhibitory activities against tyrosinase monophenolase, with IC(50)values of 3.07 +/- 0.85, 2.25 +/- 0.8 and 2.75 +/- 1.19 mu M, respectively. The inhibitory activity against monophenolase was 6- to 8-fold higher than that of kojic acid. Compounds1a,1d, and1nalso showed inhibition of diphenolase, with IC(50)values of 17.05 +/- 0.07, 11.70 +/- 0.03 and 19.3 +/- 0.28 mu M, respectively. The inhibition kinetics of diphenolase indicates that compounds1aand1dinduce reversible inhibition on tyrosinase. Finally, we found that copper coordination should be one of the important inhibitory mechanism of these compounds in tyrosinase.
COA of Formula: C15H12O. Bye, fridends, I hope you can learn more about C15H12O, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com