Recently I am researching about 5-AMINO-3-METHYL-4-ISOXAZOLECARBOXYLIC ACID HYDRAZIDE; IMMUNE-RESPONSE; ACTIVATION; INHIBITORS; PARALLEL; KINASES; JNK, Saw an article supported by the Wroclaw Medical University [SUB.D090.19.002]; Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw [504-1/2019]; Wroclaw Centre for Networking and Supercomputing [305]. Formula: C8H18O3. Published in MDPI in BASEL ,Authors: Sochacka-Cwikla, A; Regiec, A; Zimecki, M; Artym, J; Zaczynska, E; Kocieba, M; Kochanowska, I; Bryndal, I; Pyra, A; Maczynski, M. The CAS is 78-39-7. Through research, I have a further understanding and discovery of 1,1,1-Triethoxyethane
The synthesis of a series of novel 7-aminooxazolo[5,4-d]pyrimidines5, transformations during their synthesis and their physicochemical characteristics have been described. Complete detailed spectral analysis of the intermediates2-4, theN ‘-cyanooxazolylacetamidine by-products7and final compounds5has been carried out using MS, IR, 1D and 2D NMR spectroscopy. Theoretical research was carried out to explain the privileged formation of 7-aminooxazolo[5,4-d]pyrimidines in relation to the possibility of their isomer formation and the related thermodynamic aspects. Additionally, the single-crystal X-ray diffraction analysis for5hwas reported. Ten 7-aminooxazolo[5,4-d]pyrimidines5(SCM1-10) were biologically tested in vitro to preliminarily evaluate their immunological, antiviral and anticancer activity. CompoundsSCM5andSCM9showed the best immunoregulatory profile. The compounds displayed low-toxicity and strongly inhibited phytohemagglutinin A-induced proliferation of human peripheral blood lymphocytes and lipopolysaccharide-induced proliferation of mouse splenocytes. CompoundSCM9caused also a moderate suppression of tumor necrosis factor alpha (TNF-alpha) production in a human whole blood culture. Of note, the compounds also inhibited the growth of selected tumor cell lines and inhibited replication of human herpes virus type-1 (HHV-1) virus in A-549 cell line. Molecular investigations showed that the compounds exerted differential changes in expression of signaling proteins in Jurkat and WEHI-231 cell lines. The activity ofSCM5is likely associated with elicitation of cell signaling pathways leading to cell apoptosis. The compounds may be of interest in terms of therapeutic utility as inhibitors of autoimmune disorders, virus replication and antitumor agents.
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com