An article Effect of substituents in the A and B rings of chalcones on antiparasite activity WOS:000559906700001 published article about IN-VITRO; DERIVATIVES; PARASITES; ANALOGS; HIT in [Gonzalez, Luis A.; Upegui, Yulieth A.; Echeverri, Fernando; Escobar, Gustavo; Quinones, Wiston] Univ Antioquia, Inst Quim, Fac Ciencias Exactas & Nat, Grp Quim Organ Prod Nat QOPN, Calle 70 52-21, Medellin 1226, Colombia; [Upegui, Yulieth A.; Robledo, Sara M.] Univ Antioquia, Fac Med, PECET, Medellin, Colombia; [Rivas, Luis] Ctr Invest Biol, Grp Invest Peptidos Antibiot Eucariot, Madrid, Spain in 2020.0, Cited 32.0. SDS of cas: 94-41-7. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7
Chalcones are a group of natural products with many recognized biological activities, including antiparasitic activity. Although a lot of chalcones have been synthetized and assayed against parasites, the number of structural features known to be involved in this biological property is small. Thus, in the present study, 21 chalcones were synthesized to determine the effect of substituents in the A and B rings on the activity againstLeishmania braziliensis, Trypanosoma cruzi, andPlasmodium falciparum. The compounds were active againstL. braziliensisin a structure-dependent manner. Only one compound was very active againstT. cruzi, but none of them had a significant antiplasmodial activity. The electron-donating substituents in ring B and the hydrogen bonds at C-2 ‘ with carbonyl affect the antiparasitic activity.
Welcome to talk about 94-41-7, If you have any questions, you can contact Gonzalez, LA; Upegui, YA; Rivas, L; Echeverri, F; Escobar, G; Robledo, SM; Quinones, W or send Email.. SDS of cas: 94-41-7
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