In 2020.0 J ENZYM INHIB MED CH published article about MUSHROOM TYROSINASE; KOJIC ACID; EQUILIBRIUM-CONSTANTS; DERIVATIVES; PROGRAM; MECHANISM; DESIGN in [Singh, L. Ravithej; Xia, Wei; Gong, Xing-Wen; Zhou, Tao] Zhejiang Gongshang Univ, Sch Food Sci & Biotechnol, 18 Xuezheng St, Hangzhou 310018, Zhejiang, Peoples R China; [Chen, Yu-Lin; Hider, Robert C.] Kings Coll London, Div Pharmaceut Sci, London, England; [Xie, Yuan-Yuan] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou, Peoples R China in 2020.0, Cited 31.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7. Quality Control of Chalcone
In an attempt to synthesise new tyrosinase inhibitors, we designed and synthesised a series of chalcone-hydroxypyridinone hybrids as potential tyrosinase inhibitors adopting strategic modifications of kojic acid. All the newly synthesised compounds were characterised by NMR and mass spectrometry. Initial screening of the target compounds demonstrated that compounds1a,1d, and1nhad relatively strong inhibitory activities against tyrosinase monophenolase, with IC(50)values of 3.07 +/- 0.85, 2.25 +/- 0.8 and 2.75 +/- 1.19 mu M, respectively. The inhibitory activity against monophenolase was 6- to 8-fold higher than that of kojic acid. Compounds1a,1d, and1nalso showed inhibition of diphenolase, with IC(50)values of 17.05 +/- 0.07, 11.70 +/- 0.03 and 19.3 +/- 0.28 mu M, respectively. The inhibition kinetics of diphenolase indicates that compounds1aand1dinduce reversible inhibition on tyrosinase. Finally, we found that copper coordination should be one of the important inhibitory mechanism of these compounds in tyrosinase.
Quality Control of Chalcone. Welcome to talk about 94-41-7, If you have any questions, you can contact Singh, LR; Chen, YL; Xie, YY; Xia, W; Gong, XW; Hider, RC; Zhou, T or send Email.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com