1,1-Dioxo-isothiazolidine, cas is 5908-62-3, it is a common heterocyclic compound, the thiazolidine compound, its synthesis route is as follows.,5908-62-3
108371 To a solution of isothiazolidine 1,1-dioxide (500 mg, 4.13 mmol) in acetonitrile (10 mL) was added potassium carbonate (1.14 g, 8.25 mmol), 4-methoxybenzyl chloride (646 mg, 4.13 mmol). The mixture was heated to 80 C for 12 h under nitrogen atmosphere. The mixture was poured into H20 (50 mL) and extracted with ethyl acetate (50 mL). The organic layer was washed with H20 (50 mL x 2) and saturated brine solution (50 mL). The organic layers was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified via flash silica chromatography (solvent gradient: 0-40% ethyl acetate in petroleum ether) to yield 1.0 g (99% yield) of the title compound as a white solid. ?H NMR (400 MHz, CDC13) oe 7.28 (d, J= 8.4 Hz, 2H), 9.89 (d, J= 8.8 Hz, 2H), 4.13 (s, 2H), 3.82 (s, 3H), 3.23 – 3.18 (t,J= 8.8 Hz, 2H), 3.12-3.07 (m, 2H), 2.34-2.25 (m, 2H).
5908-62-3 is used more and more widely, we look forward to future research findings about 1,1-Dioxo-isothiazolidine
Reference£º
Patent; GENENTECH, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; BRAUN, Marie-Gabrielle; GIBBONS, Paul; LEE, Wendy; LY, Cuong; RUDOLPH, Joachim; SCHWARZ, Jacob; ASHKENAZI, Avi; FU, Leo; LAI, Tommy; WANG, Fei; BEVERIDGE, Ramsay; ZHAO, Liang; (652 pag.)WO2018/166528; (2018); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com