As a common heterocyclic compound, it belongs to thiazolidine compound, name is (S)-4-Phenylthiazolidine-2-thione, and cas is 185137-29-5, its synthesis route is as follows.,185137-29-5
b. 4-(S)-Phenyl-2-thione-thiazolidine-3-carboxylic acid-4-nitro-phenyl ester To a suspension of NaH (26 mg, 1.04 mmol) in 10 mL of anhydrous THF under argon, a solution of 4(S)-Phenyl-thiazolidine-2-thione (170 mg, 0.87 mmol) in THF was added dropwise via an dropping funnel. The resulting suspension was stirred at room temperature for 30 min. This suspension was then added dropwise via cannula into another round bottom flask containing a solution of 4-nitrophenylchloroformate (217 mg, 1.04 mmol) in 20 mL of THF and cooled at -78 C. over a period of 15 min. The stirring was continued for 2 h after which the solvent was removed and the residue was purified by column chromatography on silica gel with 1:1 hexane/CH2 Cl2 then 3:7 hexane/CH2 Cl2 followed by CH2 Cl2 (Rf =0.50) to obtain (+)-4(S)-phenyl-2-thione-thiazolidine-3-carboxylic acid-4-nitro-phenyl ester as a pale yellow solid (200 mg, 64%).
With the complex challenges of chemical substances, we look forward to future research findings about 185137-29-5,belong thiazolidine compound
Reference£º
Patent; Synaptic Pharmaceutical Corporation; US6159990; (2000); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com