3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid, cas is 7025-19-6, it is a common heterocyclic compound, the thiazolidine compound, its synthesis route is as follows.,7025-19-6
To a mixture of 3-(4-oxo-2-thioxothiazolidin-3-yl)propanoic acid (205 mg, 1.0 mmol), H2N-Gly-OEt hydrochloride (140 mg, 1.0 mmol) and EDC (192 mg, 1.0 mmol) in DMF (5.0 mL) was added triefhylamine (140 muEpsilon, 1.0 mmol). The reaction mixture was stirred at room temperature for 16 h, and then concentrated. The crude product was purified by flash chromatogrphy (EtOAc/Hexanes 1 :2- 1 :1) to give FX-3019 as a white solid (276 mg, 0.95 mmol, 95%): :H NMR (400 MHz, DMSO-de) delta 1.25-1.30 (t, 7 = 6.8 Hz, 3H), 2.64-2.70 (t, 7 = 7.6 Hz, 2H), 4.01 (s, 3H), 4.20-4.25 (dd, 7= 7.2, 14.0 Hz, 2H), 4.25-4.35 (t, 7 = 8.0 Hz, 2H), 6.04 (s, 1H); 13C NMR (100 MHz, DMSO-de) delta 14.1, 32.7, 35.4, 40.6, 41.4, 61.7, 169.4, 169.8, 173.6, 201.0; LC-TOF (M+H+) calcd for C10H15N2O4S2 291, found 291. Chemical Formula: C18H16BrN305S2
With the rapid development of chemical substances, we look forward to future research findings about 3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid
Reference£º
Patent; MELNICK, Ari; CERCHIETTI, Leandro, Carlos, A.; CARDENAS, Mariano, G.; XUE, Fengtian; MACKERELL, Alexander, D.; WO2014/204859; (2014); A2;,
Thiazolidine – Wikipedia
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