SDS of cas: 94-41-7. Authors Sarojini, P; Jeyachandran, M; Sriram, D; Ranganathan, P; Gandhimathi, S in ELSEVIER published article about in [Sarojini, Perumal] Sri Ramasamy Naidu Mem Coll, Dept Chem, Sattur 626203, Tamil Nadu, India; [Jeyachandran, Malaichamy; Gandhimathi, S.] Sri Paramakalyani Coll, Post Grad & Res Dept Chem, Alwarkurichi, India; [Jeyachandran, Malaichamy; Gandhimathi, S.] Manonmaniam Sundaranar Univ, Tirunelveli 627412, Tamil Nadu, India; [Sriram, Dharmarajan] Birla Inst Technol & Sci Pilani, Dept Pharm, Hyderabad Campus, Hyderabad 500078, India; [Ranganathan, Palraj] Natl Taipei Univ Technol, Inst Organ & Polymer Mat, 1,Sec 3,Chung Hsiao East Rd, Taipei 10608, Taiwan in 2021.0, Cited 33.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7
Novel 2-(aryloxymethyl)aziridines and 2((3-aryl-1-phenylallyloxy)methyl)aziridine derivatives were prepared via ring-opening reaction of epoxides. The synthesized derivatives were characterized by using elemental analysis (EA), FT-IR, C-13 NMR, and H-1 NMR. The in vitro antitubercular activities of the synthesized compounds were evaluated against Mycobacterium tuberculosis H37Rv (MTB H37Rv) strain using MTT-MABA assay. All the aziridine derivatives exhibited improved persuasive antitubercular activity against MTB H37Rv in comparison with standard drugs. Among the tested compounds, 2-(naphthalene-1-yloxy) methyl aziridine (5b), 2-(naphthalene-2-yloxy)methylaziridine (5c), 2(m-tolyloxymethyl)aziridine (5e), 2-(3-(4-methoxyphenyl)-1-phenylalloxy)methylaziridine (12b) and 2-(3(2-chlorophenyl)-1-phenylallyloxy)methylaziridine (12c) revealed promising activity against MTh H37Rv. Specifically, compound 5b and 12 b showed three-times more active (MIC = 0.5 mu g/mL) than the standard drugs ethambutol (MIC = 1.56 mu g/mL) and ciprofloxacin (MIC = 1.56 mu g/mL). (C) 2021 Elsevier B.V. All rights reserved.
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com