2-Cyanoimino-1,3-thiazolidine, cas is 26364-65-8, it is a common heterocyclic compound, the thiazolidine compound, its synthesis route is as follows.
In a dry 50 mL single-mouth flask, 10 mmol of 2-cyanoimino-1,3-thiazolidine and 5 mL of acetone were added.In an ice bath, 0.32 mL of a 50% aqueous solution of NaOH was added, and the temperature was controlled at 0C to 5C.Add dropwise a solution of 5-(2,4-difluorophenyl)-2-furanoyl chloride in acetone to control the rate ofThe temperature was kept at 0C-5C; after the addition was completed, the reaction was performed at 0C-5C for 1-2 hours and TLC test.After the reaction is completed, a 4mol/L hydrochloric acid solution is added to adjust the pH to neutrality.Dichloromethane extraction was added and the dichloromethane layer was successively saturated with sodium bicarbonate,Saturated brine and water were washed three times. The dichloromethane layer was dried over anhydrous magnesium sulfate and filtered.The compound was isolated using a silica gel column (eluent: a 2:1 volume ratio of petroleum ether to ethyl acetate).Yield 75%, 26364-65-8
With the rapid development of chemical substances, we look forward to future research findings about 2-Cyanoimino-1,3-thiazolidine
Reference£º
Patent; South China Agricultural University; Cui Zining; Xiang Xuwen; Tao Hui; Jiang Shan; Zhang Lianhui; (19 pag.)CN107674070; (2018); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com