Recently I am researching about IN-VITRO; DERIVATIVES; PARASITES; ANALOGS; HIT, Saw an article supported by the Ministerio de Ciencia, Tecnologia e Innovacion – Minciencias; Universidad de Antioquia [111571249860, 061-2016]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Gonzalez, LA; Upegui, YA; Rivas, L; Echeverri, F; Escobar, G; Robledo, SM; Quinones, W. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone. Computed Properties of C15H12O
Chalcones are a group of natural products with many recognized biological activities, including antiparasitic activity. Although a lot of chalcones have been synthetized and assayed against parasites, the number of structural features known to be involved in this biological property is small. Thus, in the present study, 21 chalcones were synthesized to determine the effect of substituents in the A and B rings on the activity againstLeishmania braziliensis, Trypanosoma cruzi, andPlasmodium falciparum. The compounds were active againstL. braziliensisin a structure-dependent manner. Only one compound was very active againstT. cruzi, but none of them had a significant antiplasmodial activity. The electron-donating substituents in ring B and the hydrogen bonds at C-2 ‘ with carbonyl affect the antiparasitic activity.
Computed Properties of C15H12O. About Chalcone, If you have any questions, you can contact Gonzalez, LA; Upegui, YA; Rivas, L; Echeverri, F; Escobar, G; Robledo, SM; Quinones, W or concate me.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com