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Structural modification of the calcium antagonist fostedil (KB-944) and their coronary vasodilator activity are described.Amidophosphonate 4a-m, lactam amidophosphonate 7a-l, and diamide dilactam 10 were prepared, and their coronary vasodilator activity was assessed in dogs.Many compounds exhibited coronary vasodilator activity superior to that of fostedil.Among them, the 2-oxopyrrolidine derivative 7a was the most effective compound.Its action as a coronary vasodilator was 3 and 2 times more potent than that of fostedil and diltiazem hydrochloride, respectively.

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Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H491N | ChemSpider