A common heterocyclic compound, the thiazolidine compound, name is 2-Cyanoimino-1,3-thiazolidine,cas is 26364-65-8, mainly used in chemical industry, its synthesis route is as follows.
Add 0.01 mol (1.28 g) to a 250 mL three-necked bottle2-cyanoimido-1,3-thiazolidine, 100 mL DMF as solvent,0.011 mol (1.52 g) of potassium carbonate as an acid binding agent, and the temperature was raised to 80 C.Stir for half an hour, then add 0.01mol (2.73g)5-(Chloromethyl)-3-(2-(2,2-difluoroethoxy)phenyl)-1,2,4-oxadiazole,Insulation reaction for 4h,TLC traces to the disappearance of the starting point and cools to room temperature.After adding 100 mL of water, stirring was continued, and a solid was precipitated and suction filtered to obtain a crude product, which was recrystallized from methanol.The compound of formula I [5-((2-cyanoimino-1,3-thiazolyl)methyl)-3-(2-(2,2-difluoroethoxy)phenyl-1,2 , 4-oxadiazole] 3.0g, yield 82.1%,
26364-65-8, As the rapid development of chemical substances, we look forward to future research findings about 26364-65-8
Reference£º
Patent; Qingdao University of Science and Technology; Xu Liangzhong; Liu Liancai; Hu Rao; Cui Huanqi; Wang Minghui; (7 pag.)CN108794462; (2018); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com