7025-19-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7025-19-6,3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid,as a common compound, the synthetic route is as follows.
General procedure: To a solution of 1,3-diaryl-4-formylpyrazoles 4 (1.0 mmol) and rhodanine analogs 5 (1.0 mmol) in absolute ethanol (8.0 mL) was added drops of acetic acid and piperidine. The reaction mixture was stirred at 40-50 C, until the completion of the reaction as evidenced by TLC. After the solution was cooled, the resulting reaction mixture was ltered off and crude product was purified by 95% ethanol to afford pure products 6-29. The yield, melting point and spectral data of each compound are given below.
The synthetic route of 7025-19-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Xu, Li-Li; Zheng, Chang-Ji; Sun, Liang-Peng; Miao, Jing; Piao, Hu-Ri; European Journal of Medicinal Chemistry; vol. 48; (2012); p. 174 – 178;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com