With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7025-19-6,3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid,as a common compound, the synthetic route is as follows.,7025-19-6
V-(2-Nitrophenyl)-3-(4-oxo-2-thioxothiazolidin-3-yl)propanamide (34b). To a suspension of 33 (100 mg, 0.48 mmol) in 4 mL of dry dichloromethane, thionyl chloride (40 mu, 0.58 mmol) was added. The reaction was monitored by TLC and after the disappearance of the starting material, 2-nitroaniline (80 mg, 0.58 mmol) was added. The resulting mixture was stirred at room temperature for 2 hours. H20 was added to the reaction mixture, then it was extracted with EtOAC, dried over Na2S04, concentrated under reduced pressure and purified with flash chromatography (hexane/EtOAc:l/l) to give the desired product 34b (130 mg, yield 84%) as a yellow solid.Mp 170-171 C. 1H NMR (400 MHz, CDC -d) delta (ppm) 10.27 (s, 1H), 8.64-8.62 (m, 1 H), 8.15-8.13 (m, 1H), 7.60-7.56 (m, 1H), 7.15-7.11 (m, 1H), 4.45 (t, J = 8, 2H), 3.94 (s, 2H), 2.22 (t, J = 8, 2H). 13C NMR (100 MHz, OMSO-d6) delta (ppm) 206.19, 173.99, 168.83, 136.04, 134.16, 128.02, 125.78, 123.59, 122.38, 40.28, 35.43, 34.87. MS (ESI) m/z: 324.4 [M-H]~. Anal. Calcd for (Ci2HiiN304S2): C, 44.30; H, 3.41; N, 12.91. Found: C, 44.36; H, 3.38; N, 12.90.
7025-19-6 3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid 81492, athiazolidine compound, is more and more widely used in various fields.
Reference£º
Patent; CONSIGLIO NAZIONALE DELLE RICERCHE; UNIVERSITA DEGLI STUDI DI SIENA; RADI, Marco; BOTTA, Maurizio; FALCHI, Federico; MAGA, Giovanni; BALDANTI, Fausto; PAOLUCCI, Stefania; WO2011/39735; (2011); A2;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com