Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like name: 5-Benzylidene-3-ethyl-2-thioxothiazolidin-4-one, Name is 5-Benzylidene-3-ethyl-2-thioxothiazolidin-4-one. In a document type is Article, introducing its new discovery., name: 5-Benzylidene-3-ethyl-2-thioxothiazolidin-4-one
Novel rhodanine derivatives induce growth inhibition followed by apoptosis
We have designed and synthesized three novel compounds, 5-isopropylidiene derivatives of 3-dimethyl-2-thio-hydantoin (ITH-1), 3-ethyl-2-thio-2,4- oxazolidinedione (ITO-1), and 5-benzilidene-3-ethyl rhodanine (BTR-1), and have tested their chemotherapeutic properties. Our results showed that all three compounds induced cytotoxicity in a time- and concentration-dependent manner on leukemic cell line, CEM. Among the compounds tested, BTR-1 was 5- to 7-fold more potent than ITH-1 and ITO-1 when compared by trypan blue and MTT assays. IC50 value of BTR-1 was estimated to be <10 muM. Both cell cycle analysis and tritiated thymidine assays revealed that BTR-1 affects DNA replication by inducing a block at S phase. BTR-1 treatment led to increased level of ROS production and DNA strand breaks suggesting activation of apoptosis for induction of cell death. If you are interested in 18331-34-5, you can contact me at any time and look forward to more communication. name: 5-Benzylidene-3-ethyl-2-thioxothiazolidin-4-one
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Quinuclidine – Wikipedia,
Quinuclidine | C7H826N | ChemSpider