With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1438-16-0,3-Aminorhodanine,as a common compound, the synthetic route is as follows.,1438-16-0
Procedure B. To a solution of RhA-8 (300 mg, 1.09 mmol) in ethanol(10 mL) was added slowly a solution of 3-amino-2-thioxothiazolidin-4-one (2, 158.2 mg, 1.09 mmol) in ethanol and was added to acetic acid(2 drops) as a catalyst. The reaction mixture was refluxed for 8 h, andwas monitored by TLC. After the completion of the reaction, the mixturewas cooled to room temperature. The red product formed wasrecrystallized from ethanol, filtered, and dried in vacuo. After recrystallization,4 (382 mg, 87%) was obtained as red solid(Mp:>300 C). 1H NMR (400 MHz, DMSO-d6): delta 12.41 (bs, NH, 1H),12.08 (bs, NH, 1H), 8.82 (s, N=CH, 1H), 8.22 (d, J=7.7 Hz, =CH,1H), 8.14-8.13 (m, =CH, 2H), 8.00-7.97 (m, =CH, 2H), 7.54-7.52 (m,=CH, 2H), 7.31-7.22 (m, =CH, 3H), 5.96 (s, =CH, 1H); 13C NMR(100 MHz, DMSO-d6): delta 206.9, 171.1, 165.7, 157.0, 147.8, 144.8,138.2, 137.3, 136.4, 135.6, 135.1, 130.7, 126.7, 124.2, 123.4, 122.3,121.6, 113.3, 112.6, 111.2, 110.3 (Fig. S9); IR (KBr, cm-1): 3242 cm-1 (=CeH), 1729 cm-1 (C]O), 1612 cm-1 (O]C-N-C]S), 1414,1315 cm-1 (C]S); ESI-MS (m/z) [M] calcd for C21H14N4OS2 402.49,found: 402.12.
As the paragraph descriping shows that 1438-16-0 is playing an increasingly important role.
Reference£º
Article; Bayindir; Caglayan, Cuneyt; Karaman, Muhammet; Guelcin, ?lhami; Bioorganic Chemistry; vol. 90; (2019);,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com