94-41-7, Name is Chalcone, molecular formula is C15H12O, belongs to thiazolidines compound, is a common compound. In a patnet, author is Reis, Maria de Graca, once mentioned the new application about 94-41-7, Quality Control of Chalcone.
Synthesis and evaluation of 2-(4-methoxy-2-oxo-1-phenyl/methyl-1, 2-dihydroquinolin-3-yl)-2-methyl-3-(phenyl/substitutedphenyl-amino)thiazolidin-4-one as antibacterial and anticancer agents
A series of 2-(4-methoxy-2-oxo-1-phenyl/methyl-1,2-dihydroquinolin-3-yl)-2-methyl-3-(phenyl/substitutedphenylamino) thiazolidin-4-one derivatives (III-a(1-5) / III-b(1-5) have been synthesized by appropriate synthetic route and satisfactorily characterized by UV-Vis, IR, NMR and mass spectral data. All synthesized compounds have been evaluated for their in vitro antibacterial and anticancer activity. Compounds have been evaluated against two Gram positive strains (Staphylococcus aureus and Bacillus subtilis) and two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa). Compound III-a2 with R-1 = C6H5 and R-2 = Cl shows promising activity against all bacterial strains with MIC between 0.25 and 4 mu g/mL. Ciprofloxacin is used as the reference standard. The compounds have also been screened for their anticancer activity against A549-human lung carcinoma cell line. Compound III-a2 (IC50 square 10 mu g) with R-1 = C6H5 and R-2 = Cl, III-a5 (IC50 = 10 mu g) with R-1 = C6H5 and R-2 = CH3 and III-b2 (IC50 = 10 mu g) with R-1 = CH3 and R-2 = Cl show 100% cell death.
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com