Reference of 2421-28-5, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 2421-28-5, Name is Benzophenone-3,3′,4,4′-tetracarboxylic dianhydride, SMILES is O=C(C1=CC2=C(C(OC2=O)=O)C=C1)C3=CC4=C(C(OC4=O)=O)C=C3, belongs to thiazolidines compound. In a article, author is Sangeetha, P., introduce new discover of the category.
New thiazoldinone substituted 2,6-diarypiperidin-4-one: Synthesis, crystal structure, spectral characterization, binding mode with calf thymus DNA
A series of 2,6-diarylpiperidin-4-ylidene thiazolidin-4-one derivatives (15-21) were efficiently synthesized using a green and recyclable catalyst Amberlit IR-120H resin under microwave irradiation. All the compounds were characterized by elemental analysis, FT-IR, H-1, C-13 NMR spectra. The conformation of the compound was unambiguously assigned by 2D NMR spectral analysis. Single crystal X-ray diffraction recorded for compound 21 and the data indicate that the compound crystallized in triclinic system with space group P (1) over bar. The observed chemical shifts and coupling constants suggested that the piperidone ring (15-21) adopts in chair conformation with equatorial orientations of the aryl groups. In solid state the configuration about C=N double bond is syn to C-5 carbon. All the compounds were screened for their in vitro antibacterial and antimycobacterial activities. Among the tested, compounds 17 and 18, were found to be potent inhibition with MIC values in the range of 0.2-0.8 mu g/mL. The interactions of the compounds with calf thymus DNA were investigated by spectroscopic method and the results indicated that compounds bound to Deoxyribo Nucleic Acid (DNA) by groove binding mode. (C) 2019 Elsevier B.V. All rights reserved.
Reference of 2421-28-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 2421-28-5.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com