Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 115-96-8, Name is Tris(2-chloroethyl) phosphate, molecular formula is C6H12Cl3O4P. In an article, author is Somasekhar, Vanita,once mentioned of 115-96-8, Name: Tris(2-chloroethyl) phosphate.
SYNTHESIS AND EVALUATION OF ANTI-PROLIFERATIVE ACTIVITY OF NOVEL THIAZOLIDINONE DERIVATIVES
A series of, 2-thioxo-4-thiazolidinone (rhodanine) and 2,4-thiazolidine-dinone derivatives were synthesized by reacting 4-thiazolidine-dione/rhodanine moieties with 2-(4-formylphenoxy)-N-substituted-phenyl-acetamide, in equimolar proportions. The authentication of synthesized compounds was done by FTIR, (HNMR)-H-1, and mass spectrophotometry. The derivatives, N-(phenyl) -2- {4-[(4-oxo-2-thioxo-1, 3-thiazolidin-5-ylidene) methyl] phenoxy} acetamide and 2-{4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)-methyl] phenoxy}-N-(phenyl)-acetamide, were further screened for their anticancer properties against CEM cell lines. Cell viability was determined by trypan blue dye exclusion assay and cytotoxic effect of the compounds by MTT assay. The two derivatives, N-(phenyl)-2-{4-[(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene) methyl] phenoxy} acetamide and 2-{4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)-methyl] phenoxy}-N-(phenyl)-acetamide were found to be anti-proliferative in nature at 75 – 100 mu M and 100 – 250 mu M concentrations, respectively. Thus, it can be established that the rhodanine derivatives, N-(phenyl) -2-{4-[(4-oxo-2-thioxo-1, 3-thiazolidin-5-ylidene) methyl]-phenoxy} acetamide and 2-{4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene) methyl] phenoxy}-N-(phenyl)-acetamide have anti-proliferative property against leukemic cell lines (lymphoblastic leukemia) and can be further optimized to improve its efficacy and safety.
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com