Related Products of 922-67-8, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 922-67-8, Name is Methyl propiolate, SMILES is C#CC(OC)=O, belongs to thiazolidines compound. In a article, author is Duy Toan Pham, introduce new discover of the category.
Antimicrobial activity of some novel 2-( 2-iodophenylimino)-5-arylidenethiazolidin-4-one derivatives
Background: Infectious diseases, especially those caused by multidrug-resistant bacteria, are becoming a serious problem worldwide because of the lack of effective therapeutic agents. Moreover, most antifungal drugs exhibit low efficacy and high toxicity because of the similarity between fungal and human cells. These issues warrant the search for potential new agents. Objectives: To synthesize potent 2-(2-iodophenylimino)-5-arylidenethiazolidin-4-one derivatives, improve the synthetic process, elucidate their structures, and determine their antimicrobial activity. Methods: 2- Iodoaniline was used as an initial reactant in a 3-step process for the synthesis of 2-(2-iodophenylimino)5-arylidenethiazolidin-4-one derivatives, including an acylation reaction, a cyclization reaction, and aldol condensation reactions. The structures of the obtained derivatives were investigated and elucidated using spectral methods. Antimicrobial activity toward 5 bacterial strains and 2 fungal strains was determined using Kirby-Bauer and agar dilution methods. Results: We successfully synthesized 12 novel compounds and elucidated their structures. The derivatives had no antifungal activities. By contrast, they showed remarkable antibacterial activities. Some of them with minimum inhibitory concentrations (MICs) <= 8 mu g/mL in both Staphylococcus aureus and methicillin-resistant S. aureus. Conclusions: A simple and flexible way to synthesize new compounds with a thiazolidin-4-one ring was determined. Some of these new compounds have outstanding effects with low MICs for bacteria. Their further investigation as therapeutic agents is warranted. Related Products of 922-67-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 922-67-8.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com