Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 99-86-5, Name is 1-Isopropyl-4-methylcyclohexa-1,3-diene, molecular formula is C10H16, belongs to thiazolidines compound, is a common compound. In a patnet, author is Neves, Arthur H. S., once mentioned the new application about 99-86-5, HPLC of Formula: C10H16.
The antinociceptive evaluation of 2,3-substituted-1,3-thiazolidin-4-ones through thermal stimulation in mice
The present study assessed the 2,3-substituted-1,3-thiazolidin-4-ones antinociceptive potential looking at the acute nociception model induced by thermal stimulation in mice. This was done to contribute to the development of new analgesic drugs, in addition to the fact that 4-thiazolidinones are an important scaffold associated with many pharmacological activities. The synthesized compounds were characterized by GC-MS and NMR of H-1 and C-13 and administered at a dose of 100 mg/kg hydrochloride salt (ip). Sodium dipyrone (250 and 500 mg/Kg; ip) and tramadol hydrochloride (25 and 50 mg/Kg; ip) were used as positive controls. The hot plate test was done at a temperature of 50 +/- 0.1 degrees C and animals assessed at 30, 60, and 90 min after the drugs were administered. Among the fourteen compounds tested, nine (5Aa, 5Ab, 5Ac, 5Ad, 5Ba, 5Bb, 5Bd, 5Ea, and 5Fa) showed significant increases in latency time when compared to saline (negative control) and compared to sodium dipyrone (500 mg/Kg; ip) in a 30-min assessment. The highest latency times were obtained for 3-(2-piperidin-1-yl)ethyl)thiazolidin-4-one derivatives (5Ab, 5Ac, and 5Ad). This highlights three findings about the chemical structure that improve activity: (i) an ethylenic link; (ii) a six-membered piperidine; (iii) an aliphatic substituent at the 2-position of thiazolidinone ring.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 99-86-5. The above is the message from the blog manager. HPLC of Formula: C10H16.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com