Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 6117-80-2, Name is (Z)-But-2-ene-1,4-diol, molecular formula is C4H8O2, belongs to thiazolidines compound, is a common compound. In a patnet, author is AboulMagd, Asmaa M., once mentioned the new application about 6117-80-2, Computed Properties of C4H8O2.
Synthesis, Antimicrobial and Molecular Modeling Studies of Some Benzophenone-based Thiazole and 4-Thiazolidinone Derivatives
New series of thiazolyl hydrazones were designed and synthesized via the reaction of benzophenone thiosemicarbazone 2 with chloroacetic acid, (un)substituted phenacylbromide and ethyl-2-chloroacetoacetate to yield compounds 3, 5a-d & 6 respectively. Furthermore, reaction of the thiazolidin-4-one 3 with aromatic aldehydes afforded compounds 4a-g. Characterization data, along with in vitro antimicrobial activity for all compounds are herein reported. All the synthesized compounds were screened against Methicillin-Resistant Staphylococcus aureus (MRSA), E. coli, K. pneumonia, P. aeruginosa, A baumannii, C. albicans and C. neoformans var.grubii. Compounds 2 and 4e showed the highest bacterial growth inhibition with 28.6% and 28.7% against MRSA, respectively. Moreover, the trisubstituted thiazole derivative 6 was the most active compound against Gram-negative bacteria A. baumannii with 59% growth inhibition. Furthermore, compounds 4e & 6 showed 22.5% and 17.3% decrease in peptidoglycan density, respectively. Molecular docking into bacterial MurB enzyme active site was used to determine their binding modein which they showed good interactions with Gln229, Arg225 and Ser82 amino acid residues.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 6117-80-2. The above is the message from the blog manager. Computed Properties of C4H8O2.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com