Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 1823-59-2, Name is 5,5′-Oxybis(isobenzofuran-1,3-dione), molecular formula is C16H6O7, belongs to thiazolidines compound, is a common compound. In a patnet, author is Desai, Nisheeth C., once mentioned the new application about 1823-59-2, Recommanded Product: 1823-59-2.
Design, synthesis, antimicrobial evaluation, and molecular docking study of some 4-thiazolidinone derivatives containing pyridine and quinazoline moiety
A series of 5-aryl-3-(4-oxo-2-phenylquinazolin-3(4H)-yl)-2-(pyridin-4-yl)thiazolidin-4-ones were synthesized and evaluated for their antibacterial and antifungal activities. Various spectral techniques e.g., IR, H-1 NMR, C-13 NMR and Mass spectrometry were used to determine structure of novel synthesized compounds. The title compounds showed good to excellent inhibition potency for respective Gram-positive bacterial strains and Gram-negative bacterial strains. These compounds exhibited a broad spectrum of inhibitory activity. Molecular docking studies against microbial DNA gyrase sub unit B could provide valuable insights into the binding affinity of these molecules and their plausible mechanism of antimicrobial action. Compounds 5a, 5d, 5f and 5h, 5i, 5j, 5o exhibited excellent activity against bacterial and fungal strains respectively.
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com