5908-62-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5908-62-3,1,1-Dioxo-isothiazolidine,as a common compound, the synthetic route is as follows.
The product of example 67 (460 mg, 8.6 mmol), sulfonamide (210 mg, 1.73 mmol), K2CO3 (240 mg, 1.73 mmol), CuI (30 mg, 0.17 mmol) and DMEDA (30 mg, 0.34 mmol) were mixed in toluene (10 ml) and heated at 90 0C for 3 hours. After being cooled to room temperature, the mixture was filtered, washed with DCM. The filtrate was concentrated into dryness, and the residue was purified by column chromatography using DCM/EA (5/2) as eluent to give the title compound (129 mg, 26.0 % yield).1H NMR (300 MHz, DMSO-/) delta 1.12 (q, J= 6.2 Hz, 6H), 2.34 (dd, J= 10.5, 12.4 Hz, IH), 2.41-2.50 (m, 2H?), 2.78 (dd, J= 10.6, 13.0 Hz, IH), 3.41-3.53 (m, 3H), 3.55-3.67 (m, IH), 3.77 (s, 3H), 3.78 -3.91 (m, 3H), 4.14 (d, J= 12.9 Hz, IH), 4.95 (d, J= 17.2 Hz, IH), 5.02 (s, 2H), 5.19 (d, J= 16.8 Hz, IH), 7.29-7.44 (m, 5H), 7.70 (s, IH).MS (ESI+) m/z 51 A (M+l)
5908-62-3 1,1-Dioxo-isothiazolidine 642157, athiazolidine compound, is more and more widely used in various.
Reference£º
Patent; AVEXA LIMITED; DEADMAN, John, Joseph; JONES, Eric, Dale; LE, Giang, Thanh; RHODES, David, Ian; THIENTHONG, Neeranat; VAN DE GRAFF, Nicholas, Andrew; WINFIELD, Lisa, Jane; WO2010/31; (2010); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com