Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 137-40-6, Name is Sodiumpropionate, molecular formula is C3H5NaO2, belongs to thiazolidines compound. In a document, author is Zehetmeyr, Fabiane Knepper, introduce the new discover, Recommanded Product: Sodiumpropionate.
Ovicidal in vitro activity of 2-aryl-3-(2-morpholinoethyl)thiazolidin-4-ones and 2-aryl-3-(3-morpholinopropyl)thiazolidin-4-ones against Fasciola hepatica (Linnaeus, 1758)
Although there is a variety of biological activity reports regarding compounds derived from thiazolidin-4-ones, no data related to ovicidal activity against trematodes, particularly Fasciola hepatica are available. Since there are reports about anthelmintic resistance in F. hepatica, new drugs are required. Thus, this study evaluated ovicidal action in vitro against F. hepatica eggs in two systematic series of thiazolidin-4-ones: 2-aryl-3-(2-morpholinoethyl)thiazolidin-4-ones (la-h) and 2-aryl-3-(3-morpholinopropyl)thiazolidin-4-ones (2a-h) at different concentrations (20, 2, 0.2, 0.02 and 0.002 mu g/ml). The egg hatch assay (EHA) was used to evaluate the ovicidal action property of such compounds. In addition, potential negative effects of the compounds on metabolic activity of bovine kidney (MDBK) cells were evaluated by determining mitochondrial dehydrogenase activity. The eggs used in the EHA were obtained from parasites removed from the liver of cattle, which were discarded by slaugh after sanitary inspection. The results of EHA showed that compounds 2a-h exhibited ovicidal activity, especially compounds 2b which showed 90% ovicidal activity and viability of 93% MDBK cells at the concentration of 2 mu g/ml; and 2e with 96-99% ovicidal activity at 0.2 mu g/ml, 0.02 mu g/ml and 0.002 mu g/ml. The results show the potential of compound 2b to continue the studies in the production of new compounds with anthelmintic action.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 137-40-6. Recommanded Product: Sodiumpropionate.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com