Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 108-59-8, Name is Dimethylmalonate, molecular formula is C5H8O4, belongs to thiazolidines compound, is a common compound. In a patnet, author is Abu Bakr, Sherifa M., once mentioned the new application about 108-59-8, Name: Dimethylmalonate.
Synthesis and anticancer evaluation of novel isoxazole/pyrazole derivatives
The key intermediate 3-amino-5-methylisoxazole (1) was allowed to react with phthalic anhydride and/or maleic anhydride under different conditions to produce different isoxazole products. Schiff bases 9a-c obtained via the reaction of 1 with different aldehydes were condensed with thioglycolic acid to afford the corresponding thiazolidin-4-one derivatives 10a, b. Furthermore, condensation of the Schiff bases 9a, c with various secondary amines produced the corresponding 5-substituted pyrazole derivatives 11a-d, respectively. The anticancer activity of some of the newly synthesized compounds was evaluated against Panc-1 and Caco-2 cell lines using doxorubicin as a standard drug. Most of the tested derivatives exhibited high cytotoxic potency against Panc-1 carcinoma cell lines, but moderate to weak activity was obtained against Caco-2 cell lines.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 108-59-8. The above is the message from the blog manager. Name: Dimethylmalonate.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com