What I Wish Everyone Knew About C3H3NOS2

Synthetic Route of 141-84-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 141-84-4.

Synthetic Route of 141-84-4, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 141-84-4, Name is Rhodanine, SMILES is O=C1CSC(=S)N1, belongs to thiazolidines compound. In a article, author is Liu, Ke, introduce new discover of the category.

A novel diacylglycerol kinase alpha-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response

Diacylglycerol kinase (DGK) consists of 10 isozymes. The alpha-isozyme enhances the proliferation of cancer cells. However, DGK alpha facilitates the nonresponsive state of immunity known as T-cell anergy; therefore, DGK alpha enhances malignant traits and suppresses immune surveillance. The aim of this study was to identify a novel small molecule that selectively and potently inhibits DGK alpha activity. We screened a library containing 9,600 chemical compounds using a newly established high-throughput DGK assay. As a result, we have obtained a promising compound, 5-[(2E)-3-(2-furyl)prop-2-enylidene]-3-[(phenylsulfonyl) amino]2-thioxo-1,3-thiazolidin-4-one) (CU-3), which selectively inhibited DGK alpha with an IC50 value of 0.6 mu M. CU-3 targeted the catalytic region, but not the regulatory region, of DGK alpha. CU-3 competitively reduced the affinity of DGK alpha for ATP, but not diacylglycerol or phosphatidylserine. Moreover, this compound induced apoptosis in HepG2 hepatocellular carcinoma and HeLa cervical cancer cells while simultaneously enhancing the interleukin-2 production of Jurkat T cells. Taken together, these results indicate that CU-3 is a selective and potent inhibitor for DGK alpha and can be an ideal anticancer drug candidate that attenuates cancer cell proliferation and simultaneously enhances immune responses including anticancer immunity.

Synthetic Route of 141-84-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 141-84-4.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com