In an article, author is Shrivastava, Sushant K., once mentioned the application of 6118-51-0, Name is exo-3,6-Epoxy-1,2,3,6-tetrahydrophthalic Anhydride, molecular formula is C8H6O4, molecular weight is 166.13, MDL number is MFCD00151506, category is thiazolidines. Now introduce a scientific discovery about this category, HPLC of Formula: C8H6O4.
Design, synthesis and evaluation of novel thiazolidinedione derivatives as anti-hyperglycemic and anti-hyperlipidemic agents
A novel series of thiazolidine-2,4-diones was designed, synthesized and investigated for anti-diabetic activity. The (2,4-dioxo-1,3-thiazolidin-5-yl)methylphenylbenzamide derivatives contain an amide linkage between the central aryl ring and the hydrophobic tail. Structures of the compounds were confirmed by spectroscopic techniques fourier transform infrared spectroscopy, H-1-nuclear magnetic resonance and elemental (C, H, N) analysis. The synthesized compounds were evaluated for their in-vivo pharmacological activity (blood glucose and triglyceride lowering activity), where compounds thiazolidinediones-C and thiazolidinediones-E showed significant effects, comparable to the standard pioglitazone. Computational studies positively substantiated the nature and interaction of the designed compounds with peroxisome proliferator-activated receptor gamma.
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com