Chemistry is an experimental science, Safety of 2,2-Bis(hydroxymethyl)butyric acid, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 10097-02-6, Name is 2,2-Bis(hydroxymethyl)butyric acid, molecular formula is C6H12O4, belongs to thiazolidines compound. In a document, author is Chen, Hua.
Design, synthesis and immunomodulating activity of C-pseudonucleosides containing thiazolidin-4-one and phenyl connected by acetamide bond
Several novel C-pseudonucleosides containing thiazolidin-4-one and phenyl connected by acetamide bond were rationally designed and easily synthesized at room temperature by using the unprotected sugar aldehyde as the starting material. The effects of the compounds on Con A-induced T cell proliferation were evaluated at five concentrations of 5, 10, 25, 50, and 100 mu mol/L Interestingly, compounds 7a and 8a = 2, R = H) exhibited immunostimulating activities, while compounds 5a, 6a (n = 1, R = H) and 7b, 8b (n = 2, R = CH3) showed immunosuppressive activities. Another two compounds 5b and 6b (n = 1, R = CH3) had no immunomodulating activities. These initial biological results suggested that subtle structural changes to the phenyl and acetamide bond of C-pseudonucleosides could have a significant effect on T cell proliferation bias, although it was difficult to formulate a rigorous structure activity relationship based on the observed activities. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 10097-02-6, in my other articles. Safety of 2,2-Bis(hydroxymethyl)butyric acid.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com