Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 115-96-8, Name is Tris(2-chloroethyl) phosphate, molecular formula is C6H12Cl3O4P. In an article, author is Imrich, Jan,once mentioned of 115-96-8, Name: Tris(2-chloroethyl) phosphate.
Unexpected regiospecific formation and DNA binding of new 3-(acridin-9-yl)methyl-2-iminothiazolidin-4-ones
New 3-(acridin-9-yl)methyl-2-substituted imino-1,3-thiazolidin-4-ones were regiospecifically synthesized from unstable (acridin-9-yl)methyl thioureas and methyl bromoacetate (MBA) or bromoacetyl bromide (BAB). Unexpected formation of only one thiazolidinone regioisomer with both the reagents was due to a new mechanism involving a transient spiro 9,10-dihydroacridine intermediate. These results are in contrast with the reactions of acridin-9-yl thioureas with MBA/BAB that afforded two different thiazolidinone regioisomers with these reagents. UV-vis titrations, CD spectra, and fluorescence quenching have shown that new products intercalated into calf thymus (CT) DNA, and displaced ethidium bromide (EB) from a CT DNA EB complex. Intrinsic binding constants, K-b, and Stern-Volmer constants, K-SV, were found in the range 0.79×10(5) -2.85×10(5) M-1 and 17950-3360 M-1, respectively. The strongest binding affinity was found for an electron donated 2-(4-methoxyphenylimino)thiazolidinone. Additional evidence for DNA intercalation was obtained from thermal denaturation studies. Gel electrophoresis has proven that thiazolidinone products nicked the supercoiled plasmid DNA in 5.0 mu M concentration.
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com