The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. SDS of cas: 29681-57-0, 29681-57-0, Name is tert-Butyldimethylsilane, SMILES is C[SiH](C(C)(C)C)C, in an article , author is Zhou, Tao-Shun, once mentioned of 29681-57-0.
Thiazolidin-2-cyanamides derivatives as novel potent Escherichia coli beta-glucuronidase inhibitors and their structure-inhibitory activity relationships
Gut microbial beta-glucuronidases have the ability to deconjugate glucuronides of some drugs, thus have been considered as an important drug target to alleviate the drug metabolites-induced gastrointestinal toxicity. In this study, thiazolidin-2-cyanamide derivatives containing 5-phenyl-2-furan moiety (1-13) were evaluated for inhibitory activity againstEscherichia coli beta-glucuronidase (EcGUS). All of them showed more potent inhibition than a commonly used positive control,d-saccharic acid 1,4-lactone, with the IC(50)values ranging from 1.2 mu M to 23.1 mu M. Inhibition kinetics studies indicated that compound1-3were competitive type inhibitors for EcGUS. Molecular docking studies were performed and predicted the potential molecular determinants for their potent inhibitory effects towards EcGUS. Structure-inhibitory activity relationship study revealed that chloro substitution on the phenyl moiety was essential for EcGUS inhibition, which would help researchers to design and develop more effective thiazolidin-2-cyanamide type inhibitors against EcGUS.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 29681-57-0, you can contact me at any time and look forward to more communication. SDS of cas: 29681-57-0.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com