Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 97-90-5, Name is Ethane-1,2-diyl bis(2-methylacrylate), molecular formula is C10H14O4, belongs to thiazolidines compound. In a document, author is Buemi, Maria Rosa, introduce the new discover, Product Details of 97-90-5.
Inhibition of HIV-1 RT activity by a new series of 3-(1,3,4-thiadiazol-2-yl) thiazolidin-4-one derivatives
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) represent potent anti-HIV agents targeting HIV-1 reverse transcriptase (RT), a crucial enzyme for the viral life cycle. We have previously identified a series of NNRTIs bearing a 2,3-diaryl-1,3-thiazolidin-4-one core and some compounds proved to be effective in inhibiting HIV-1 replication at micromolar concentration. As a continuation in this research work we report the design, the synthesis and the structure-activity relationship studies of a further series of 3-(1,3,4-thiadiazol-2-yl)thiazolidin-4-one derivatives containing an arylthioacetamide group as pharmacophoric structural requirement for binding to the RT catalytic area. The new compounds proved to be effective to inhibit RT activity at micromolar concentrations. Finally, docking studies were carried out in order to rationalize the biological results of the new synthesized inhibitors.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 97-90-5. Product Details of 97-90-5.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com