Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Quality Control of Chalcone, 94-41-7, Name is Chalcone, SMILES is O=C(C1=CC=CC=C1)/C=C/C2=CC=CC=C2, belongs to thiazolidines compound. In a document, author is Piatkowska-Chmiel, Iwona, introduce the new discover.
THE ANALGESIC EFFECT OF 1,3-THIAZOLIDIN-4-ONE DERIVATIVES AS POTENTIAL MODULATORS OF THE SEROTONINERGIC SYSTEM
This study presents the synthesis and evaluation of the analgesic effect of 1,3-thiazolidin-4-one derivatives. Tested compounds were prepared by the cyclization reaction of appropriate N-substituted carboxylic acid hydrazide derivatives with mercaptoacetic acid. The purpose of this study was the evaluation of the analgesic properties of 1,3-thiazolidin-4-one derivatives. In addition to this, we tried to explain the role of serotonin receptors in the antinociceptive mechanisms of tested compounds. The experiments were carried out using male Albino Swiss mice (20-25g). The compounds were administered intraperitoneally (ip) and were analysed for analgesic activities in models of pain in mice. Additionally, they were tested for safety on the central nervous system of mice in selected behavioural tests. Our results revealed an interesting analgesic activity of the tested compounds. The tested derivatives showed low toxicity, reflected by their LD50 value. Moreover, none of these compounds exhibited neurotoxic properties or impaired the cognitive activity of mice, even at the highest doses used. All tested derivatives showed analgesic activity. Among the tested compounds, N-[2-(4-methylphenyl)-4-oxo-1,3-thiazolidin-3-yl] acetamide seems to be the most effective painkiller. It has a pronounced antinociceptive effect towards thermal and mechanical pain stimulation. The present results support the idea that 5-HT receptors play an important role in the control of pain. The compounds that modulate 5-HT receptors activity may have clinical utility in pain therapy.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 94-41-7 is helpful to your research. Quality Control of Chalcone.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com