Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 1823-59-2, Name is 5,5′-Oxybis(isobenzofuran-1,3-dione), SMILES is O=C1OC(C2=C1C=CC(OC3=CC4=C(C(OC4=O)=O)C=C3)=C2)=O, in an article , author is Gowramma, B., once mentioned of 1823-59-2, Safety of 5,5′-Oxybis(isobenzofuran-1,3-dione).
Synthesis of Some Novel 2-Azetidinones/4-Thiazolidinones Bearing 1, 3, 4-Thiadiazole Nucleus and Screening for its Anti-Imflammatory Activity
Objective: The objective of the study was to synthesize a series of 3-chloro-4-(substituted phenyl)-1-(5-styryl-1, 3, 4-thiladiazole-2-yl) azetidin-2-one / 2-(substituted phenyl)-3-(5-styryl-1, 3, 4-thiadiazole-2-yl)-thiazolidin-4-one and screened for their possible anti-inflammatory activity by carrageenan induced paw edema in rats. Method: The synthesis of 2-amino-5-styryl-1, 3, 4-thiadiazole, an intermediate was carried out by oxidative cyclization method. In the current study, thiosemicarbazone (I) was subjected to oxidative cyclization using ferric chloride as an oxidising agent, to get 2-amino-5-styryl-1, 3, 4-thiadiazole (II). Futhermore, compound (II) was reacted with different aromatic aldehydes in methanol to form N-(4-sustituted)-5-styryl-1, 3, 4-thiadiazol-2-amine (III a-h). Compound (III a-h) was reacted with chloroacetyl chloride in triethylamine to form 2-azetidinone derivatives bearing 1, 3, 4-thiadiazole nucleus (IV a-h). Compound (III a-h) on cyclocondensation with mercaptoacetic acid leads to the formation of 4-thiazolidinone derivatives bearing 1, 3, 4-thiadiazole nucleus (V a-h). Results: The synthesis of the targeted compounds IV a-h and Va-h was confirmed through their MP, IR, H-1-NMR and mass spectrum studies. Compounds IVa, IVb and IVc (56.32, 61.11 and 58.24 % inhibition) exhibited significant anti-inflammatory activity than that of diclofenac (65.13% inhibition). Conclusion: It may be concluded that the presence of methoxy, nitro and hydroxyl phenyl groups substituting 2-azetidinone bearing 1, 3, 4-thiadiazole showed significant anti-inflammatory activity.
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com