Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 10097-02-6, Name is 2,2-Bis(hydroxymethyl)butyric acid, molecular formula is C6H12O4. In an article, author is Latif, N. A. Abdel,once mentioned of 10097-02-6, Quality Control of 2,2-Bis(hydroxymethyl)butyric acid.
Synthesis, Characterization, and Anticancer Screening of Some New Bithiazole Derivatives
Twenty new bithiazole derivatives were synthesized by condensation of 2-{2-[(1-arylethylidene)hydrazinylidene]thiazolidin-4-ylidene}hydrazine-1-carbothioamides with halo ketones, halo esters, and alpha-keto hydrazonoyl halides. The structures of all prepared compounds were proposed on the basis of their IR,H-1 and(13)C NMR, and mass spectra. All the synthesized compounds were screened for their cytotoxicity against three human cancer cell lines, HCT-116 (human colorectal carcinoma), MCF-7 (human breast adenocarcinoma), and HepG2 (human hepatocellular carcinoma). Two compounds (12dand12b) had significantly more potent anticancer activity on HCT-116 human colorectal carcinoma cells. In the case of MCF-7 human breast cancer cells, three compounds (12b,4band4a) were significantly more potent than the reference drug doxorubicin. Nine of the synthesized compounds (8a,7a,9b,12d,12c,7b,10a,5aand12b) showed a significantly higher activity than that of doxorubicin against HepG2 human liver cancer cells.
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com