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Synthesis and Antibacterial Activity of Carbazole and Fluorobenzylidene Substituted Thiazolidine-2,5-diones
Thizolidine-2,4-dione on reaction with p-fluorobenzaldehyde in the presence of piperidine and toluene gave (Z)-5-(4-fluorobenzylidine)thiazolidin-2,4-dione (1), which on reaction with carbazole and substituted benzaldehydes in the presence of ethanol yielded (Z)-5-(4-fluorobenzylidene)-3-[(9H-carbazole-9-yl) (2-substituted phenyl)methyl]thiazolidine-2,4-diones (2a-2j). These compounds were screened for their antibacterial activity against Gram-positive bacterial strains such as Bacillus subtilis and Staphylococcus aureus as well as Gram-negative bacterial strains such as Escherichia coli and Pseudomonas aeruginosa. Among the tested compounds 2c and 2d showed significant activity against Gram-positive bacterial strains, and compound 2g was found to be most active against Gram-negative bacterial strains. [GRAPHICS]
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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com