Electric Literature of 7025-19-6, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, Electric Literature of 7025-19-6, name is 3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid, introducing its new discovery.
In Silico Driven Design and Synthesis of Rhodanine Derivatives as Novel Antibacterials Targeting the Enoyl Reductase InhA
Here, we report on the design, synthesis, and biological evaluation of 4-thiazolidinone (rhodanine) derivatives targeting Mycobacterial tuberculosis (Mtb) trans-2-enoyl-acyl carrier protein reductase (InhA). Compounds having bulky aromatic substituents at position 5 and a tryptophan residue at position N-3 of the rhodanine ring were the most active against InhA, with IC50 values ranging from 2.7 to 30 muM. The experimental data showed consistent correlations with computational studies. Their antimicrobial activity was assessed against Mycobacterium marinum (Mm) (a model for Mtb), Pseudomonas aeruginosa (Pa), Legionella pneumophila (Lp), and Enterococcus faecalis (Ef) by using anti-infective, antivirulence, and antibiotic assays. Nineteen out of 34 compounds reduced Mm virulence at 10 muM. 33 exhibited promising antibiotic activity against Mm with a MIC of 0.21 muM and showed up to 89% reduction of Lp growth in an anti-infective assay at 30 muM. 32 showed high antibiotic activity against Ef, with a MIC of 0.57 muM.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 7025-19-6 is helpful to your research. Electric Literature of 7025-19-6
Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H814N | ChemSpider