Application of 7025-19-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.7025-19-6, Name is 3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid, molecular formula is C6H7NO3S2. In a Article£¬once mentioned of 7025-19-6
In Silico Driven Design and Synthesis of Rhodanine Derivatives as Novel Antibacterials Targeting the Enoyl Reductase InhA
Here, we report on the design, synthesis, and biological evaluation of 4-thiazolidinone (rhodanine) derivatives targeting Mycobacterial tuberculosis (Mtb) trans-2-enoyl-acyl carrier protein reductase (InhA). Compounds having bulky aromatic substituents at position 5 and a tryptophan residue at position N-3 of the rhodanine ring were the most active against InhA, with IC50 values ranging from 2.7 to 30 muM. The experimental data showed consistent correlations with computational studies. Their antimicrobial activity was assessed against Mycobacterium marinum (Mm) (a model for Mtb), Pseudomonas aeruginosa (Pa), Legionella pneumophila (Lp), and Enterococcus faecalis (Ef) by using anti-infective, antivirulence, and antibiotic assays. Nineteen out of 34 compounds reduced Mm virulence at 10 muM. 33 exhibited promising antibiotic activity against Mm with a MIC of 0.21 muM and showed up to 89% reduction of Lp growth in an anti-infective assay at 30 muM. 32 showed high antibiotic activity against Ef, with a MIC of 0.57 muM.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 7025-19-6, and how the biochemistry of the body works.Application of 7025-19-6
Reference£º
Quinuclidine – Wikipedia,
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