The Absolute Best Science Experiment for 4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile

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Ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/C[sbnd]Cu catalysis

A convenient synthetic method has been developed for accessing 2,6-dialkynyl-3,5-dichloropyridine derivatives in acceptable to good yields. The methodology involved ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/C[sbnd]Cu catalysis. A variety of terminal alkynes were employed in this C[sbnd]C coupling reaction to afford the corresponding 2,6-dialkynyl-3,5-dichloropyridine derivatives.

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