One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: (S)-4-Isopropylthiazolidine-2-thione, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 76186-04-4, Name is (S)-4-Isopropylthiazolidine-2-thione, molecular formula is C6H11NS2
Total synthesis of the lipid mediator PD1n-3 DPA: Configurational assignments and anti-inflammatory and pro-resolving actions
The polyunsaturated lipid mediator PD1n-3 DPA (5) was recently isolated from self-resolving inflammatory exudates of 5 and human macrophages. Herein, the first total synthesis of PD1n-3 DPA (5) is reported in 10 steps and 9% overall yield. These efforts, together with NMR data of its methyl ester 6, confirmed the structure of 5 to be (7Z,10R,11E,13E,15Z,17S,19Z)-10,17- dihydroxydocosa-7,11,13,15,19-pentaenoic acid. The proposed biosynthetic pathway, with the involvement of an epoxide intermediate, was supported by results from trapping experiments. In addition, LC-MS/MS data of the free acid 5, obtained from hydrolysis of the synthetic methyl ester 6, matched data for the endogenously produced biological material. The natural product PD1 n-3 DPA (5) demonstrated potent anti-inflammatory properties together with pro-resolving actions stimulating human macrophage phagocytosis and efferocytosis. These results contribute new knowledge on the n-3 DPA structure-function of the growing numbers of specialized pro-resolving lipid mediators and pathways.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: (S)-4-Isopropylthiazolidine-2-thione, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 76186-04-4, in my other articles.
Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H713N | ChemSpider