1,3-Dipolar cycloaddition reaction on carbohydrate template: Stereoselective synthesis of glyco-spiro-heterocycles was written by Prasanna, R.;Purushothaman, S.;Raghunathan, R.. And the article was included in Tetrahedron in 2020.Synthetic Route of C4H7NO2S This article mentions the following:
A simple and an efficient stereoselective synthesis of glyco-spiro-heterocycles has been accomplished via 1, 3-dipolar cycloaddition (1,3-DC) reaction. The azomethine ylide generated by decarboxylative condensation of N-alkylated α-amino acids with various diketones was trapped by sugar derived dipolarophiles to give glyco-spiro-heterocycles in good yield (72-94%). All the cycloadducts were well characterized by FT IR, NMR, HRMS and HPLC. The structures were established by 2D NMR. The regio- and stereochem. outcome of some of the cycloadducts were confirmed by a single crystal X-ray anal. Effect of various solvents on 1, 3 DC reaction was also studied. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Synthetic Route of C4H7NO2S).
Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Synthetic Route of C4H7NO2S
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com