A Convenient Synthesis of Thiazolidin-2-ones from Thiazolidine-2-thiones: Antibiotic Activity and Revisiting the Mechanism was written by Deng, Xiao-Bing;Chen, Ning;Wang, Zhi-Xin;Li, Xin-Yao;Hu, Hong-Yan;Xu, Jia-Xi. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2011.Computed Properties of C6H11NS2 This article mentions the following:
Various substituted thiazolidin-2-ones were synthesized from the corresponding thiazolidine-2-thiones with bromoethanol in ethanol with sodium ethoxide as a base. The optimal reaction conditions and mechanism were reinvestigated in detail. The bioassay indicated that (S)-4-iso-butylthiazolidin-2-one and (S)-4-benzylthiazolidin-2-one show certain inhibitive activities against Candida albicans and Escherichia coli. In the experiment, the researchers used many compounds, for example, (S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4Computed Properties of C6H11NS2).
(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine is an important scaffold and has a wide range of promising biological activities. Thiazolidine derivatives have reported anti-inflammatory and anti-nociceptive activity. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Computed Properties of C6H11NS2
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com