Month: December 2022

Mild and highly efficient method for the synthesis of arylidenethiazolidinone analogues was written by Chandrappa, S.;Vinaya, K.;Prasanna, D. S.;Rangappa, K. S.. And the article was included in Proceedings of the Indian National Science Academy in 2011.Category: thiazolidine This article mentions the following:

A new, convenient method for the syntheses of arylidenethiazolidinone analogs e. g., I from gem-dibromomethylarenes and 2,4-thiazolidindiones under mild conditions is described. Short reaction times, large-scale synthesis, easy and quick isolation of the products, and excellent yields are the main advantages of this method. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Category: thiazolidine).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine is an important scaffold and has a wide range of promising biological activities. Thiazolidine derivatives have reported anti-inflammatory and anti-nociceptive activity. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Category: thiazolidine

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Synthesis of 3-substituted-2,4-dioxothiazolidine derivatives from 1-substituted-4,4,6-trimethyl-1,4-dihydropyrimidine-2(3H)-thiones was written by Singh, Harjit;Singh, Paramjit;Deep, Kanwal. And the article was included in Chemistry & Industry (London, United Kingdom) in 1981.Recommanded Product: 16312-21-3 This article mentions the following:

The pyrimidinethiones I (R = Ph, C₆H₄Me-p, C₆H₄NO₂–p, C₆H₄Me-o, Me) were treated with aqueous ClCH₂CO₂H to give the corresponding thiazolidines II in good yields. The mechanism involves initial condensation of the acid at the S atom, followed by protonation, ring cleavage, cyclodehydration, and hydrolysis to give II. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Recommanded Product: 16312-21-3).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Recommanded Product: 16312-21-3

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Ceriometric studies of thiazolidinedione and some of its 3-substituted derivatives was written by Turkevich, N. M.;Dmitrishin, R. T.. And the article was included in Vestnik L’vovskogo Politekhnicheskogo Instituta in 1975.Name: 3-Methylthiazolidine-2,4-dione This article mentions the following:

Thiazolidinedione (I; R = H) was oxidized by aqueous Ce4+ to give S2(CH2CO2H)2 (II), NH4+, and CO2; I (R = Me) gave II, MeNH3+, and CO2 under the same conditions. Analogous treatment of I (R = C6H4OEt-p) afforded I (R = C6H4OH-p) and AcOH, an excess Ce4+ converted I (R = C6H4OH-p, Ph) to II, benzoquinone, CO2, and N. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Name: 3-Methylthiazolidine-2,4-dione).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Name: 3-Methylthiazolidine-2,4-dione

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

The Role of Water in the Catalyst-Free Aldol Reaction of Water-Insoluble N-Methyl-2,4-thiazolidinedione with N-Methylisatin from QM/MM Monte Carlo Simulations was written by Zhao, Jianming;He, Fen;Zhang, Fan;Yang, Xin;Tian, Zhiyue;Xue, Ying. And the article was included in ChemPhysChem in 2017.Category: thiazolidine This article mentions the following:

The role of water in the uncatalyzed aldol reaction of N-methyl-2,4-thiazolidinedione with N-methylisatin is investigated through Monte Carlo statistical mechanics simulations that utilize free energy perturbation theory and the mixed quantum mechanics and mol. mechanics (QM/MM) model with PDDG/PM3 for the QM method in “on-water” and DMSO environments. There are several conceivable orientations between thiazolidinedione and isatin in the process of C-C bond formation. However, the formation of the C-C bond takes place between the re face of isatin and the si face of (E)-enol of the thiazolidinedione to form the preferred anti-type product, which results from enhanced hydrogen-bonding interactions between water mols. and the oxygen atoms undergoing bond breakage and bond formation during the reaction. Novel insights into the effect of water on the aldol reaction are presented herein. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Category: thiazolidine).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Category: thiazolidine

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Site-Specific Chemical Modification of Peptide and Protein by Thiazolidinediones was written by Wang, Peng;Zhang, Shumei;Meng, Qiuyue;Liu, Ying;Shang, Luqing;Yin, Zheng. And the article was included in Organic Letters in 2015.Reference of 16312-21-3 This article mentions the following:

A direct aldol reaction employing 2,4-thiazolidinediones as nucleophilic donors was performed to modify peptides and protein under mild conditions. Various functional groups could be readily introduced into protein without conformation change. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Reference of 16312-21-3).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Thiazolidines unsubstituted on the nitrogen atom are readily hydrolyzed by boiling aqueous solutions of acids or bases and the dissociation is complete in the presence of a compound reacting with one of the cleavage products.Reference of 16312-21-3

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Vicarious nucleophilic substitution of hydrogen proceeding via heterocyclic ring opening was written by Makosza, Mieczyslaw;Sypniewski, Michal;Glinka, Tomasz. And the article was included in Tetrahedron in 1996.Related Products of 16312-21-3 This article mentions the following:

Carbanions of five-membered S-heterocycles react with nitroarenes via the ring-opening VNS reaction or oxidative nucleophilic substitution of hydrogen. The reaction course is affected by rigidity of the ring. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Related Products of 16312-21-3).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Related Products of 16312-21-3

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

2-Aminothiazolin-4-one and 2-iminothiazolidin-4-one derivatives. I. The reaction of chloroacetic acid with N-monoalkylthiourea was written by Akerblom, Eva. And the article was included in Acta Chemica Scandinavica (1947-1973) in 1967.COA of Formula: C4H5NO2S This article mentions the following:

The reaction of ClCH2CO2H with N-alkylthioureas in the presence of NaOAc gave II. The same reaction performed in the absence of a base gave varying results depending on the size of the alkyl substituent. Thus, with N-methylthiourea, I (R = Me) was obtained. With N-ethyl- and N-propylthiourea, the corresponding I and II were both obtained in the proportions 3-4:1. The reaction with N-isopropylthiourea gave exclusively II (R = iso-Pr) (III). In acidic media, the 2-alkylamino compounds (II) rearranged to the 3-alkyl compounds I while under alk. conditions the reaction was reversed. III did not rearrange. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3COA of Formula: C4H5NO2S).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.COA of Formula: C4H5NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Design, synthesis, in silico molecular modelling studies and biological evaluation of novel indole-thiazolidinedione hybrid analogues as potential pancreatic lipase inhibitors was written by George, Ginson;Auti, Prashant S.;Paul, Atish T.. And the article was included in New Journal of Chemistry in 2021.Related Products of 16312-21-3 This article mentions the following:

Pancreatic lipase (PL) is a key enzyme responsible for the digestion of dietary triglycerides; hence its inhibition is considered as a promising target for the management and/or treatment of obesity. A new series of indole-thiazolidinedione (TZD) hybrid analogs were synthesized using a mol. hybridization approach and evaluated for their anti-obesity effects via PL inhibition. The targeted analogs were synthesized via the condensation reaction between various substituted isatin with TZD in the presence of aqueous KOH in methanol. Amongst the synthesized analogs, 7k and 7m exhibited a potential PL inhibitory activity (IC50 – 7.30 and 9.51μM, resp.). Kinetic study of these potent analogs revealed their competitive mode of enzyme inhibition. This fact was confirmed via fluorescence spectroscopy which further suggested the presence of one binding site for the synthesized analogs. Mol. docking of the synthesized analogs was performed using human PL (PDB ID: 1LPB). The obtained MolDock scores were aligned with the in vitro PL inhibitory activity (Pearson’s r = 0.9108, p < 0.05). Moreover, a stable conformation of the 1LPB-ligands suggested the stability of these complexes in the dynamic environment. These studies provided a basis for the potential role of the indole-TZD hybrids in PL inhibition and further optimization might result in the development of new lead candidates for obesity treatment. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Related Products of 16312-21-3).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidines undergo hydrolysis to aldehyde and amino thiol under acid or basic aqueous conditions. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Related Products of 16312-21-3

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Optimization of troglitazone derivatives as potent anti-proliferative agents: Towards more active and less toxic compounds was written by Bordessa, Andrea;Colin-Cassin, Christelle;Grillier-Vuissoz, Isabelle;Kuntz, Sandra;Mazerbourg, Sabine;Husson, Gauthier;Vo, Myriam;Flament, Stephane;Martin, Helene;Chapleur, Yves;Boisbrun, Michel. And the article was included in European Journal of Medicinal Chemistry in 2014.Formula: C4H5NO2S This article mentions the following:

Δ2-Troglitazone derivatives were shown to exhibit anti-proliferative activity in a PPARγ-independent manner. We prepared various compounds in order to increase their potency and decrease their toxicity towards non-malignant primary cultured hepatocytes. Many compounds induced viabilities less than 20% at 10 μM on various cancer cell lines. Furthermore, five of them showed hepatocyte viability of 80% or more at 200 μM. In addition, compounds 17 and 18 exhibited promising maximum tolerated doses on a murine model, enabling future investigations. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Formula: C4H5NO2S).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Formula: C4H5NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Syntheses of mesoionic thiazole compounds disubstituted amino group was written by Ohta, Masaki;Sato, Shigeru. And the article was included in Nippon Kagaku Zasshi in 1968.Recommanded Product: 3-Methylthiazolidine-2,4-dione This article mentions the following:

4-Thiazone in this abstract refers to the structural skeleton I. Various possibilities of formation of 4-thiazone derivatives were examined PhNHCS2Et (5 g.), 3.5 g. BrCH2CO2H (II), 3 g. Et3N, and 30 ml. C6H6 heated 3 hrs. at 40° gave an oil, probably PhN: C(SEt)SCH2CO2H, which failed to give a 4-thiazone derivative on treatment with Ac2O and Et3N. N-(N-Phenylthiocarbamoyl)morpholine (III) in 100 ml. C6H6 treated with 6 g. Et3N and 6.5 g. II and treated with 15 ml. Ac2O and Et3N after evaporation gave 9.2 g. 5-acetyl-2-morpholino-3-phenyl-4-thiazone (IV) (R = morpholino), m. 249° (decomposition). Similarly the following IV were obtained [R, m.p. (decomposition), and % yield given]: Me2N, 251-3°, 60; Et2N, 208°, 50; Bu2N, 220°, 40; pyrrolidino, 298-300°, 70; and piperidino, 218°, 70. Hydrolysis of IV with dilute HCl gave 3-phenyl-2,4-thiazolidinedione. Attempted preparation of 4-thiazones with no Ac group at position-5 failed. N-Benzamidomorpholine (10 g.) in 100 ml. pyridine treated with 10 g. P2S5 at 130° gave 9 g. N-thiobenzamidomorpholine (V), m. 147-8°. Treating 4.5 g. V in 100 ml. C6H6 with 2.8 g. II and 3 g. Et3N 2 hrs. at 70° and treating with Ac2O and Et3N after evaporation gave 0.5 g. solid, m. 170°, which analyzed correctly for 5-acetyl-3-morpholino-2-phenyl-4-thiazone but had ir absorptions at 1680 and 1760 cm.-1 III (2.2 g.) and 1.4 g. II in 30 ml. C6H6 refluxed 2 hrs. gave 3-phenyl-2,4-thiazolidinedione. Similarly 3-methyl-2,4-thiazolidinedione, b5 95-7°, m. 35-6°, was prepared In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Recommanded Product: 3-Methylthiazolidine-2,4-dione).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. Thiazolidine is prepared as it was in its first reported synthesis, by the condensation of cysteamine and formaldehyde. Other thiazolidines may be synthesized by similar condensations. A notable derivative is 4-carboxythiazolidine, derived from formaldehyde and cysteine.Recommanded Product: 3-Methylthiazolidine-2,4-dione

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com