Month: December 2022

Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation was written by Kotha, Sambasivarao;Sreevani, Gaddamedi;Dzhemileva, Lilya U.;Yunusbaeva, Milyausha M.;Dzhemilev, Usein M.;D’yakonov, Vladimir A.. And the article was included in Beilstein Journal of Organic Chemistry in 2019.Computed Properties of C4H5NO2S This article mentions the following:

A new synthetic approach was reported to assemble spirothiazolidinediones via a [2 + 2 + 2] cyclotrimerization reaction and the derivatives were further functionalized through DA chem. and click reaction. Using flow cytometry, it was shown for the first time that the new benzyl alc. derivatives of thiazolidine-2,4-dione generated here are efficient apoptosis inducers in the HeLa, Hek293, U937, Jurkat, and K562 cell lines. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Computed Properties of C4H5NO2S).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Computed Properties of C4H5NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

2,4-Thiazolidinedione derivatives was written by Turkevich, N. M.;Yurzhenko, S. A.. And the article was included in Khim. Geterotsikl. Soedin., Sb. 3 in 1971.Synthetic Route of C4H5NO2S This article mentions the following:

Reaction of 2,4-thiazolidinedione (I) with KOH gave the K salt which with Me2SO4 or the appropriate halogen compound gave the following II (R and % yield given): Me, 65; Et, 46; CH2CO2Me, 62; Et2NCH2CH2, 46; PhCH2, 85; 2,4-(O2N)2C6H3, 30. Heating I K salt with an acyl chloride gave the following II (same data given): Bz, 64; p-O2NC6H4CO, 56; Ph2CHCO, 42; Ph2CClCO, 62. Reaction of I with p-O2NC6H4CHO gave 85% III (R = H), which with KOH, then RCl gave 76% III (R = PhCH2) (IV), and 69% III (R = Et2NCH2CH2). Refluxing IV with N2H4.H2O in alc. gave the azine. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Synthetic Route of C4H5NO2S).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Synthetic Route of C4H5NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

New Benzylidenethiazolidinediones as Antibacterial Agents was written by Heerding, Dirk A.;Christmann, Lisa T.;Clark, Tammy J.;Holmes, David J.;Rittenhouse, Stephen F.;Takata, Dennis T.;Venslavsky, Joseph W.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2003.Safety of 3-Methylthiazolidine-2,4-dione This article mentions the following:

A novel benzylidenethiazolidinedione has been discovered with antimicrobial activity. Here, we present the results of a structure-activity study on this compound with respect to its antimicrobial activity. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Safety of 3-Methylthiazolidine-2,4-dione).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Safety of 3-Methylthiazolidine-2,4-dione

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Reaction of O-alkyl-N-substituted iminothiocarbonates with bromoacetyl bromide. A general method for the synthesis of 3-substituted 1,3-thiazolidine-2,4-diones was written by Imrich, Jan;Bernat, Juraj;Kristian, Pavol;Busova, Tatiana;Hocova, Slavka. And the article was included in Collection of Czechoslovak Chemical Communications in 1996.Application In Synthesis of 3-Methylthiazolidine-2,4-dione This article mentions the following:

Reaction of O-methyl-N-substituted iminothiocarbonate sodium salts RN:C(OMe)SNa [R = (substituted) 9-acridinyl, Me, (substituted) Ph, 1-naphthyl, 1-naphthylmethyl] with bromoacetyl bromide represents a new general method for preparation of 3-substituted 1,3-thiazolidine-2,4-diones I in good yields and high purity. The structure of the synthesized products has been confirmed by ¹H NMR, ¹³C NMR, IR, and mass spectroscopy as well as by independent synthesis. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Application In Synthesis of 3-Methylthiazolidine-2,4-dione).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Application In Synthesis of 3-Methylthiazolidine-2,4-dione

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Oxidation of thiocarbamidates. 10. α-Carbamoyl sulfoxides and sulfones. 2. Formation of thiosulfonates by hydrolysis of cyclic α-carbamoyl sulfoxides was written by Hanefeld, Wolfgang;Jalili, Mohamed A.. And the article was included in Liebigs Annalen der Chemie in 1986.SDS of cas: 16312-21-3 This article mentions the following:

RNHCOCH₂CH₂SO₂SCH₂CH₂CONHR (R = Me, Ph, PhCH₂, PhCH₂CH₂) and RNHCOCH₂SO₂SCH₂CONHR (R = Ph, PhCH₂, p-ClC₆H₄CH₂) were prepared by hydrolysis of the thiazine oxides I and thiazolidine oxide II. Structures were confirmed by independent synthesis. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3SDS of cas: 16312-21-3).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidines undergo hydrolysis to aldehyde and amino thiol under acid or basic aqueous conditions. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.SDS of cas: 16312-21-3

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Synthesis and properties of 2,4-thiazolidinedione derivatives was written by Turkevich, N. M.;Yurzhenko, S. A.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii, Sbornik in 1971.Recommanded Product: 3-Methylthiazolidine-2,4-dione This article mentions the following:

Heating 2,4-thiazolidinedione K salt, (I, R1 = K, R2 = H2) (II) or its 5-p-nitrobenzylidene derivative (I, R1 = K, R2 = CHC6H4NO2-p) with alkylating agent in Me2CO or DMF gave 3-alkyl derivatives [I, R1 = Me, Et, CH2CO2Me, (CH2)2NEt2, CH2Ph, C6H3-(NO2)2-3,4]. II and acyl halides in Me2CO yielded 3-acyl derivatives [I, R1 = Bz, COC6H4NO2-p, COCHPh2, COCClPh2]. Refluxing I (R1 = CH2Ph, R2 = CHC6H4NO2-p) with N2H4.H2O in EtOH 3 hr gave p-nitrobenzaldazine. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Recommanded Product: 3-Methylthiazolidine-2,4-dione).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Recommanded Product: 3-Methylthiazolidine-2,4-dione

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

An uncatalyzed aldol reaction of thiazolidinediones was written by Paladhi, Sushovan;Chauhan, Ajay;Dhara, Kalyan;Tiwari, Ashwani Kumar;Dash, Jyotirmayee. And the article was included in Green Chemistry in 2012.Recommanded Product: 16312-21-3 This article mentions the following:

Thiazolidinediones have been used as aldol donors with aromatic aldehydes “on water” and in DMSO without using any catalyst to give the corresponding β-hydroxy carbonyl compounds in high yield and purity. The p-cyano and p-nitro substituted aldol products undergo syn/anti isomerization via an enolization mechanism providing an “on water” diastereoselectivity switch. Water mols. play a significant role in stabilizing the syn aldol products of pyridine and thiazole containing aldehydes. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Recommanded Product: 16312-21-3).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. In the thiazolidine nucleus, a large number of substitutions are possible on 2, 4 and 5 positions responsible for enhancing the compound’s pharmaceutical importance. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Recommanded Product: 16312-21-3

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Discovery and optimisation studies of antimalarial phenotypic hits was written by Mital, Alka;Murugesan, Dinakaran;Kaiser, Marcel;Yeates, Clive;Gilbert, Ian H.. And the article was included in European Journal of Medicinal Chemistry in 2015.Computed Properties of C4H5NO2S This article mentions the following:

There is an urgent need for the development of new antimalarial compounds As a result of a phenotypic screen, several compounds with potent activity against the parasite Plasmodium falciparum were identified. Characterization of these compounds is discussed, along with approaches to optimize the physicochem. properties. The in vitro antimalarial activity of these compounds against P. falciparum K1 had EC₅₀ values in the range of 0.09-29 μM, and generally good selectivity (typically >100-fold) compared to a mammalian cell line (L6). One example showed no significant activity against a rodent model of malaria, and more work is needed to optimize these compounds In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Computed Properties of C4H5NO2S).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Computed Properties of C4H5NO2S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Design and synthesis of amino acid derivatives containing hydantoin and thiazolidine moieties was written by Kotha, Sambasivarao;Gaikwad, Vidyasagar. And the article was included in Journal of Chemical Sciences (Berlin, Germany) in 2022.Name: 3-Methylthiazolidine-2,4-dione This article mentions the following:

A simple synthetic approach to N-Me spiro hydantoins such as I and thiazolidine containing amino acid derivatives such as 5,6-bis(bromomethyl)-3′-methyl-1,3-dihydrospiro[indene-2,5′-thiazolidine]-2′,4′-dione by coupling 1,2,4,5-tetrakis(bromomethyl) benzene with Et isocyanoacetate (EICA) as a glycine equivalent was reported. Normally, α-amino acids are derived from hydantoin, wherein the hydantoin and amino acid moieties are incorporated in the same mols. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Name: 3-Methylthiazolidine-2,4-dione).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Name: 3-Methylthiazolidine-2,4-dione

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Oxidation of thiourethanes, XII: Oxidative desulfuration of cyclic dithiocarbamates and -carbazates using hydrogenperoxide or hydrogenperoxide/sodium tungstate in a two-phase-system was written by Hanefeld, Wolfgang;Schlitzer, Martin. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 1994.Reference of 16312-21-3 This article mentions the following:

Cyclic dithiocarbamates and dithiocarbazates were desulfurized to the corresponding 2-oxo-analogs using H₂O₂ with or without addition of Na₂WO₄ in a 2-phase-system. For example, desulfuration of compounds I (R = alkyl, amino, etc.; n = 1,2) were converted into thiazolidinediones II (same R). Desulfuration of 3-Methyl-2-thioxo-4-thiazolidinone gave 3-Methyl-2,4-thiazolidinedione. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Reference of 16312-21-3).

3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine derivatives have been found to exhibit very prominent anti-inflammatory and anti-nociceptive activity. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Reference of 16312-21-3

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com