Month: April 2022

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Shibata, Katsuyoshi; Saito, Yoshiyuki; Matsui, Masaki; Takase, Yoshimi researched the compound: Bromoferrocene( cas:1273-73-0 ).Product Details of 1273-73-0.They published the article 《Alkoxylation of ferrocene by photolysis of haloferrocenes in aqueous alcohols》 about this compound( cas:1273-73-0 ) in Bulletin of the Chemical Society of Japan. Keywords: ferrocene alkoxylation; photolysis haloferrocene alkoxylation; alc alkoxylation haloferrocene. We’ll tell you more about this compound (cas:1273-73-0).

The UV irradiation of haloferrocenes I (R = Cl, Br, iodo) in aq R1OH (R1 = Me, Et, Pr, CHMe2, CMe3) resulted in an alcoholysis with the formation of 8-60% of the corresponding alkoxyferrocenes I (R = OR1) and 5-28% ferrocene. The order of the reactivities of I was R = iodo > Br > Cl.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Some transformations of 2,4-dimethylpyrrole》. Authors are Fischer, Hans; Weiss, Bernhard; Schubert, Max.The article about the compound:Ethyl 3,5-Dimethyl-2-pyrrolecarboxylatecas:2199-44-2,SMILESS:O=C(C1=C(C)C=C(C)N1)OCC).Formula: C9H13NO2. Through the article, more information about this compound (cas:2199-44-2) is conveyed.

From 0.9 g. 2,4-dimethylpyrrole (I) and 0.8 g. MeCN in cold Et2O saturated with dry HCl and allowed to stand 1 day is obtained 0.7 g. of the ketimine, m. 100°, sublimes 100° (HCl salt, green needles), of 2,4-dimethyl-5-acetylpyrrole (II). The ketimine is reduced by H and Pt sponge in alc. to I and when boiled with H2O to disappearance of the NH3 odor, 0.7 g. of it gives 0.3 g. II, m. 121°. 2,4-Dimethyl-5-chloroacetylpyrrole (0.9 g. from 1 g. I and 1 g. MeCN in cold Et2O saturated with dry HCl and allowed to stand 0.5 hr. in ice), m. 143°, gives in alc. with 30% NHMe2 after 0.5 hr. at 100° the 5-dimethylaminoacetyl derivative, m. 110°, while 0.5 g. boiled 0.5 min. in alc. with 40% HCHO and a few drops concentrated HCl yields 0.4 g. bis-[2,4-dimethyl-5-chloroacetylpyrryl]methane, m. 258°, which with NHMe2 in alc. gives the bis-5-dimethylaminoacetyl derivative m. 170°. I (1 g.) boiled up several times with 2 g. of 90% HCO2H and 10 drops of 20% HClO4 and allowed to stand 1 day gives 0.5 g. of the perchlorate, becomes discolored 200°, does not m. 260°, of bis-[2,4-dimethyl-pyrryl]methene, yellow, m. 117°. 2,4-Dimethyl-5-carbethoxypyrrole (III), obtained in 60-70% yield from I and EtMgBr and subsequent treatment with ClCO2Et, m. 125°, gives a positive Ehrlich aldehyde reaction in the cold, is hydrolyzed by boiling 50% KOH to the free acid, m. 136°, also obtained from the above Grignard compound with CO2. 2,4-Dimethyl-5-carbethoxypyrrole-3-aldehyde (IV). obtained in 85% yield from III and HCN in cold Et2O saturated with dry HCl and subsequent decomposition of the resulting imide chloride with hot H2O, m. 145°, gives a faint Ehrlich aldehyde reaction in the cold, more strongly on heating; 3 g. heated with 1:1 KOH until completely dissolved (about 15 min.) gives 2.2 g. of the free 5-carboxyaldehyde, m. 230°, which on distillation in vacuo yields 2,4-dimethylpyrrole-3-aldehyde, m. 126°, gives a positive aldehyde reaction even in the cold. Phenylhydrazone of IV, m. 204°. Azlactone, C19H18O4N2 (1.3 g. from 1.2 g. IV, 1.8 g. hippuric acid, 2.2 g. NaOAc and 20 cc. Ac2O heated 35 min. on the H2O bath), m. 232°. Oxime, m. 196-7°, converted by boiling NaOAc-Ac2O into the nitrile, C10H12O2N2, m. 171°. Semicarbazone, m. 285° (decomposition), converted by Na in alc. after 8 hrs. at 160-70° into 2,3,4-trimethylpyrrole. 2,4-Dimethyl-5-carbethoxy-3-chloroacetylpyrrole, from III and ClCH2CN, m. 163°, gives a faint positive Ehrlich reaction on heating, is highly sternutatory when powdered, gives in boiling alc. with aqueous KCN the 3-cyanoacetyl derivative, m. 172-3°.

Here is just a brief introduction to this compound(2199-44-2)Formula: C9H13NO2, more information about the compound(Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate) is in the article, you can click the link below.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-(7-Bromo-1H-indol-3-yl)acetic acid( cas:63352-97-6 ) is researched.COA of Formula: C10H8BrNO2.Luebbe, Claus; Van Pee, Karl Heinz; Salcher, Olga; Lingens, Franz published the article 《The metabolism of tryptophan and 7-chlorotryptophan in Pseudomonas pyrrocinia and Pseudomonas aureofaciens》 about this compound( cas:63352-97-6 ) in Hoppe-Seyler’s Zeitschrift fuer Physiologische Chemie. Keywords: tryptophan chlorotryptophan metabolism Pseudomonas. Let’s learn more about this compound (cas:63352-97-6).

P. pyrrocinia ATCC 15958 and a mutant strain (ACN) of P. aureofaciens ATCC 15926 possess a mechanism for the degradation of the tryptophan side chain. Indole, indole-3-carboxylic acid, indole-3-acetic acid, the corresponding compounds chlorinated or brominated at position 7, indole-3-pyruvate, and 7-chloroindole-3-pyruvate were isolated from bacterial cultures. The chlorinated indole derivatives were isolated after the addition of 7-chloro-DL-tryptophan to cultures of P. pyrrocinia whereas their bromo analogs were found in the culture medium of the mutant strain ACN of P. aureofaciens, grown in the presence of NaBr. Enzymic studies show that tryptophan is transaminated to indole-3-pyruvate, which is transformed to indole-3-acetaldehyde. Dehydrogenation of indole-3-acetaldehyde leads to indole-3-acetic acid, which is further metabolized to indole-3-carboxaldehyde and converted by dehydrogenation to indole-3-carboxylic acid. Indole is formed by the spontaneous decarboxylation of indole-3-carboxylic acid.

Here is just a brief introduction to this compound(63352-97-6)COA of Formula: C10H8BrNO2, more information about the compound(2-(7-Bromo-1H-indol-3-yl)acetic acid) is in the article, you can click the link below.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1273-73-0, is researched, Molecular C10BrFe, about Redox-Rich Metallocene Tetrazene Complexes: Synthesis, Structure, Electrochemistry, and Catalysis, the main research direction is cobaltocene ferrocene tetrazene cobalt complex preparation electronic structure; electrolysis catalyst proton reduction cobaltocene tetrazene cobalt complex.Formula: C10BrFe.

Thermal or photochem. metal-centered cycloaddition reactions of azidocobaltocenium hexafluorophosphate or azidoferrocene with (cyclooctadiene)(cyclopentadienyl)Co(I) afforded the first metallocenyl-substituted tetrazene cyclopentadienyl cobalt complexes together with azocobaltocenium or azoferrocene as side products. The trimetallic CpCo compounds are highly conjugated, colored and redox-active metallo-aromatic compounds, as shown by their spectroscopic, structural and electrochem. properties. The CpCo-tetrazenido complex with two terminally appended cobaltocene units catalyzes electrochem. proton reduction from acetic acid at a mild overpotential (0.35 V). Replacing cobaltocene with ferrocene moieties rendered the complex inactive toward catalysis.

Here is just a brief introduction to this compound(1273-73-0)Formula: C10BrFe, more information about the compound(Bromoferrocene) is in the article, you can click the link below.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Bromoferrocene, is researched, Molecular C10BrFe, CAS is 1273-73-0, about Crystal and molecular structure of the complex boron triferrocenyl-pyridine.Quality Control of Bromoferrocene.

X-ray study of the title tris(ferrocenyl)boron pyridine complex confirms that in the solid state its structure is similar to that inferred from chem. and spectroscopic evidence. The B atom is coordinated by 3 ferrocenyl groups and a pyridine ring in a distorted tetrahedral array. The mol. has a nearly 3-fold axis normal to the plane defined by the ferrocenyl groups. The B-N distance of 1.656 (5) Å is larger than that obtained for other compounds studied. The pyridine and cyclopentadienyl rings are planar. The H atoms of the cyclopentaidenyl rings are displaced significantly toward their corresponding Fe atom. The mols. in the crystal are packed at normal van der Waals distances. No unusually short intermol. contacts are noted.

Here is just a brief introduction to this compound(1273-73-0)Quality Control of Bromoferrocene, more information about the compound(Bromoferrocene) is in the article, you can click the link below.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate( cas:2199-44-2 ) is researched.HPLC of Formula: 2199-44-2.Takaya, Hikaru; Kojima, Sachiko; Murahashi, Shun-Ichi published the article 《Rhodium Complex-Catalyzed Reaction of Isonitriles with Carbonyl Compounds: Catalytic Synthesis of Pyrroles》 about this compound( cas:2199-44-2 ) in Organic Letters. Keywords: isonitrile reaction ketone rhodium catalyst; pyrrole preparation isonitrile reaction ketone rhodium catalyst. Let’s learn more about this compound (cas:2199-44-2).

Low-valent rhodium complexes are efficient catalysts for the activation of α-C-H bond of isonitriles. Addition of isonitriles to carbonyl compounds proceeds under mild and neutral conditions to give the corresponding α,β-unsaturated formamides. Catalytic synthesis of pyrroles can be performed by cyclocondensation of isonitriles with 1,3-dicarbonyl compounds Et 3,4,5-trimethyl-2-pyrrolecarboxylate was obtained in 68% yield and converted to octamethylporphyrin by a standard method.

Here is just a brief introduction to this compound(2199-44-2)HPLC of Formula: 2199-44-2, more information about the compound(Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate) is in the article, you can click the link below.

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SDS of cas: 1273-73-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Bromoferrocene, is researched, Molecular C10BrFe, CAS is 1273-73-0, about Synthesis, characterization and cytotoxicity of some palladium(II), platinum(II), rhodium(I) and iridium(I) complexes of ferrocenylpyridine and related ligands. Crystal and molecular structure of trans-dichlorobis(3-ferrocenylpyridine)palladium(II). Author is Rajput, Jaisheila; Moss, John R.; Hutton, Alan T.; Hendricks, Denver T.; Arendse, Catherine E.; Imrie, Christopher.

The preparation of a series of ferrocenyl nitrogen donor ligands including ferrocenylpyridines, ferrocenylphenylpyridines and 1,1′-di(2-pyridyl)ferrocene is described. Coordination studies of the substituted pyridines (L) were carried out with platinum, palladium, rhodium and iridium. This resulted in the preparation of the following types of complexes: [MCl(CO)2(L)] and [M(cod)(L)2]ClO4 where M = Rh or Ir, cod = 1,5-cyclooctadiene; [M’Cl2(L)2] where M’ = Pt or Pd. The X-ray crystal structure of trans-dichlorobis(3-ferrocenylpyridine)palladium was obtained. The complexes were screened for activity against two human cancer cell lines. At least two of the complexes displayed growth inhibition similar to that of the widely used chemotherapeutic agent, cisplatin.

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Synthetic Route of C10BrFe. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Bromoferrocene, is researched, Molecular C10BrFe, CAS is 1273-73-0, about Reactions of haloferrocenes. III. Reaction of haloferrocenes with copper(I) benzenethiolate, thiocyanate, acetate, and benzoate. Author is Sato, Masaru; Motoyama, Izumi; Hata, Kazuo.

Iodoferrocene reacted with copper(I) benzenethiolate in boiling pyridine to give ferrocenyl Ph sulfide in a quant. yield. The reaction of iodoferrocene with copper(I) thiocyanate gave diferrocenyl disulfide. The behavior of copper(I) acetate and benzoate toward haloferrocene was different from those of the other copper(I) salts: reactions in boiling pyridine gave the corresponding ferrocenyl ester, together with a small quantity of ferrocene, while the reaction in boiling toluene produced biferrocenyl as the main product. The reaction mechanism of the ferrocenyl ester and biferrocenyl formations was discussed.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2199-44-2, is researched, Molecular C9H13NO2, about New method for synthesis of (ω-chloroalkyl)pyrroles, the main research direction is chloroalkylpyrrolecarboxylate preparation; pyrrole chloroalkyl derivative preparation.Category: thiazolidine.

Et 4-(ω-chloroalkyl)-3,5-dimethyl-1H-pyrrole-2-carboxylates (alkyl = Et, Pr, butyl) were prepared in >96% yields from Et 4-(ω-chloroacyl)-3,5-dimethyl-1H-pyrrole-2-carboxylates by treatment with NaBH4 followed by BF3·Et2O in THF. The ω-chloroacyl derivatives were prepared from 2-(ethoxycarbonyl)-3,5-dimethylpyrrole (1) by Friedel-Crafts reaction in >91% yields. 1 Was prepared in one step from 2,4-pentanedione and di-Et aminomalonate or di-Et oximinomalonate according to literature methods.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 15965-55-6, is researched, SMILESS is O=[N+](C1=C2NC(Cl)=NC2=CC=C1)[O-], Molecular C7H4ClN3O2Journal, Khimiko-Farmatsevticheskii Zhurnal called Synthesis and biological activity of 5,6-dinitro derivatives of benzimidazole, Author is Chernova, E. Yu.; Mokrushina, G. A.; Chupakhin, O. N.; Kotovskaya, S. K.; Il’enko, V. I.; Andreeva, O. T.; Boreko, E. I.; Vladyko, G. V.; Korobchenko, L. V., the main research direction is virucide dinitrobenzimidazole; benzimidazole dinitro virucide bactericide; bactericide dinitrobenzimidazole.SDS of cas: 15965-55-6.

The title compounds I [R = H·HCl, Me; R1 = NH2NH, amino, azolyl (II)] were prepared from chlorobenzimidazoles I [R1 = Cl (III)]. III in turn, were prepared by the nitration of 2-chlorobenzimidazole. The antiviral and antimicrobial activity of II were examined

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