Month: April 2022

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate( cas:2199-44-2 ) is researched.Quality Control of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate.Jones, R. Alan; Rustidge, David C.; Cushman, Susan M. published the article 《Pyrrole studies. XXX. A critical evaluation of the Knorr synthesis of trifluoromethylpyrroles and the reactivity of diethyl 4-trifluoromethyl-2-methylpyrrole-3,5-dicarboxylate》 about this compound( cas:2199-44-2 ) in Synthetic Communications. Keywords: pyrrolecarboxylate ester trifluoromethyl derivative; Knorr synthesis trifluoromethylpyrrole; nitrosation trifluoroacetoacetate. Let’s learn more about this compound (cas:2199-44-2).

Pyrroles I (R = CO2Et, COMe) were prepared from F3CCOCH2CO2Et (II) and MeCOCH2R. II was nitrosated in HOAc, the mixture was refluxed, MeCOCH2CO2Et was added, Zn dust was introduced, and the new mixture was refluxed to give I (R = CO2Et). The nitrosation of MeCOCH2CO2Me and treatment of the product with II and Zn gave pyrrole III.

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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Bromoferrocene(SMILESS: Br[C-]12[Fe+2]3456789([C-]%10C6=C7C8=C9%10)C1=C3C4=C25,cas:1273-73-0) is researched.Recommanded Product: 2199-44-2. The article 《Moessbauer investigation of some derivatives of ferrocenes》 in relation to this compound, is published in Inorganica Chimica Acta. Let’s take a look at the latest research on this compound (cas:1273-73-0).

The Moessbauer parameters of a series of ferrocene derivatives were determined The isomer shift values were independent from the nature of the substituent on the cyclopentadiene ring. The differences in the quadrupole splitting values gave information on the changes caused by the substituents in the electronic structure of the Fe central atom. The Moessbauer parameters were interpreted on the basis of MO-LCAO-SCF calculations of Shustorovich and Dyatkina. The results were in better accord with these than with the analogous calculations of Dahl and Ballhausen.

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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2199-44-2, is researched, Molecular C9H13NO2, about Improved synthesis of covalently strapped porphyrins. Application to highly deformed porphyrin synthesis, the main research direction is porphyrin strapped; polymethyleneporphyrin.Recommanded Product: 2199-44-2.

The title porphyrins I (n = 1, 2, 3) were prepared α,ω-Dicarboxyalkyl dichloride, was treated with 2 equiv of 2-(ethoxycarbonyl)-3,5-dimethylpyrrole, and the chain-linked bis[5-(ethoxycarbonyl)pyrrole] so obtained was transformed into the pyrrole-2-carboxaldehyde by using standard methodol. Protection of the formyl groups as the dicyanovinyl derivative and the activation of the 2-Me substituents with SO2Cl2 gave the bis[2-(chloromethyl)pyrrol)], which on reaction with a 5-unsubstituted 2-pyrrolecarboxylate, in warm AcOH, afforded the chain-linked dipyrromethane dimer in high yield. Regeneration of the formyl substituents and removal of the ester group produced the 5-formyldipyrromethane dimer II, which was cyclized intramolecularly, under high dilution, to give I. II (n = 0) failed to cyclize.

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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Infrared absorption studies. XI. NH-H and NH-O bonds》. Authors are Buswell, A. M.; Downing, J. R.; Rodebush, W. H..The article about the compound:Ethyl 3,5-Dimethyl-2-pyrrolecarboxylatecas:2199-44-2,SMILESS:O=C(C1=C(C)C=C(C)N1)OCC).Name: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate. Through the article, more information about this compound (cas:2199-44-2) is conveyed.

cf. C. A. 34, 4663.8. Data are given for the IR absorption of acetylglycine Et ester in solution and for the solid, for 3,5-dimethyl-2-carbethoxypyrrole in solution, for diphenylamine in CCl4 solution, for the solids and for mixtures of diphenylamine and dimethylacetamide and for solid films of acetamide, trichloroacetamide, n-valeramide, sulramic acid, glycine and diketopiperazine. These data indicate that intermol. NHN bonds show a fundamental IR absorption near 3 μ. These bonds are formed only when the first N is relatively much more acidic than the second N. NH-O bonds are formed only with a semipolar O. The bonding observed by IR studies in amides and the peptide linkage is believed to be NHO- with absorption near 3.0 μ if isolated but at 3.22 μ if the bonds are formed in pairs. A coplanar structure is postulated for the CONHR group which involves geometrical isomerism. This structure must be considered in any explanation of protein behavior.

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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Some reactions of 2,4-dimethylmagnesylpyrrole》. Authors are Ingraffia, F..The article about the compound:Ethyl 3,5-Dimethyl-2-pyrrolecarboxylatecas:2199-44-2,SMILESS:O=C(C1=C(C)C=C(C)N1)OCC).HPLC of Formula: 2199-44-2. Through the article, more information about this compound (cas:2199-44-2) is conveyed.

Because of the anomalous behavior of magnesylpyrrole with SOCl2 (I) and CS2 (cf. Oddo and Mingoia, C. A. 21, 1458), it was decided to study their action as well as that of ClCO2Et (II) on a little studied derivative of pyrrole, viz., 2,4-dimethylpyrrole (III) in the form of its magnesyl derivative (IV), and on magnesylpyrroles with neg. radicals (to stabilize the ring). IV and II in anhydrous Et2O, heated, and decomposed with ice, yield Et 2,4-dimethyl-5-pyrrolecarboxylate, HN.CMe:CH.CMe:CCO2Et (V), slightly yellow, m. 124°. I in Et2O added to ice-cold IV (2 mols.) in Et2O, after standing decomposed with ice, neutralized with NaHCO3 and purified with difficulty (Et2O, petr. ether, Me2CO and C6H6), yields 3,5,3′,5′-tetramethylpyrro-(2,2′)-sulfone, (HN.CMe:CH.CMe:C)2SO2, dark violet, decomposes around 95° stable toward hot alk. hydroxides, is not reduced by Zn and AcOH, is decomposed with evolution of H2S by Sn in hot HCl. Ag derivative, probably an α’-derivative IV and CS2 in Et2O heated, decomposed with ice, acidified with H2O4, the Et2O-soluble product treated with aqueous NaOH, and acidified when ice-cold, precipitates 2,4-dimethyl-5-dithiopyrrolecarboxylic acid, HN.CMe:CH.CMe:CC(:S)SH (VI), also obtained directly but very impure by drying the Et2O-soluble portion (loc. cit.). It is unstable and immediately oxidizes to 2,4-dimethylthiopyrrole disulfide, [HN.CMe:CH.CMe:CC(:S)S-]2, red, m. 156°. With neutral Pb(OAc)2, the aqueous Na salt (VII) of VI precipitates the Pb salt, [HN.CMe:CH.CMe:CC(:S)S]2Pb, yellow. In darkness, aqueous VI and AgNO3 precipitate the Ag salt, HN.CMe:CH.CMe:CC(:S)SAg, brick-red. No Zn salt is precipitated from aqueous VII and Zn(OAc)2. It was then to be determined whether with a compound containing a neg. CO2Et group, e. g., V, the reaction with EtMgBr is normal, and if so to determine the behavior of the new metal derivative in comparison with III. Actually V and EtMgBr in anhydrous Et2O evolve C2H6 and form the magnesyl derivative (VIII), BrMgN.CMe:CH.CMe:CCO2Et or HN.CMe:C(MgBr).CMe:CCO2Et, yellowish oil. Heated with CS2 or with AcCl in anhydrous Et2O, VIII remains unaltered. This incapacity to react probably depends upon the assumption of the enolic form, N:CMe.CH:CMe.C:C(OMgBr)OEt, as was found with alkyl pyrryl ketones by Oddo (C. A. 19, 2492; Gazz. chim. ital. 40, ii, 15(1910); cf. C. A. 4, 2460).

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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Bromoferrocene, is researched, Molecular C10BrFe, CAS is 1273-73-0, about Ring opening of ferrocenyl-substituted cyclopropanes.SDS of cas: 1273-73-0.

Treating a mixture of isomeric ferrocenyl-substituted cyclopropanes I (R = Fc throughout this abstract) with excess Ph3CBF4 in CH2Cl2 gave a 2:1 mixture of endo and exo isomers of diferrocenyl-substituted cyclohexene II, formed by cyclodimerization of the initially formed butadiene. Cleavage of 3-methyl-3-ferrocenylcyclopropene with CF3CO2H followed by trapping with excess Me2NPh gave a mixture of E- and Z-4-Me2NC6H4CH2CH:CRMe. A mechanism involving ferrocenyl-stabilized carbocation formation is proposed.

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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 530-66-5, is researched, Molecular C9H9NO4S, about Synthesis, characterization and photochromic properties of novel spirooxazines, the main research direction is spiro indoline naphthoxazine preparation photochromism merocyanine.Quality Control of quinoliniumhydrogensulphate.

A series of spirooxazine compounds were synthesized via condensation reaction of 1,3,3-trimethyl-2-methyleneindoline with 1-nitroso-2,7-naphthalenediols, followed by esterification with acyl chlorides. Absorption bands in the visible region were observed in UV spectra (λmax: 530-665 nm), which were red-shifted as the polarity of solvent increased. Furthermore, these absorption bands also red-shifted with the increase of the electron-donating ability of the 6′-heterocycle substituent, but were nearly unaffected by 9′-acyloxy. Thermal decoloration showed that the thermal relaxation progress of the photomerocyanine followed 1st order kinetics and the relaxation time was tuned in a broad range from 125-1886 s (at 20°) by changing electron-donating power on 6′-heterocycle and 9′-acyloxy.

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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Computed Properties of C7H4ClN3O2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Chloro-7-nitro-1H-benzo[d]imidazole, is researched, Molecular C7H4ClN3O2, CAS is 15965-55-6, about Heterocyclic betaines. XXII. Azinium(azolium) 4-nitrobenzimidazolate inner salts and their derivatives with several interannular spacers. Synthesis, characterization and antitrichomonal activity. Author is Alcalde, Ermitas; Perez-Garcia, Lluiesa; Dinares, Immaculada; Frigola, Jordi.

The synthesis of an ensemble of pyridinium(imidazolium) 4-nitrobenzimidazolate betaines and their derivatives with several interannular linkages has been explored. Their antiprotozoal activity has also been examined

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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2199-44-2, is researched, Molecular C9H13NO2, about Dithiocarboxylic acids of pyrroles. II. Friedel-Crafts reactions with carbon disulfide, the main research direction is pyrrole dithiocarboxylic acid preparation; dithiocarboxylic acid pyrrole preparation; Friedel Crafts reaction carbon disulfide; carbon disulfide Friedel Crafts reaction.Related Products of 2199-44-2.

Reaction of 2,4-dimethyl-5-(ethoxycarbonyl)pyrrole (I) with AlCl3 in CS2 gave 10% 3-(dithiocarboxy) derivative (II) of I. The same reactions in the presence of ClCO2Et gave the Et ester of II. 2-Methyl-3-(ethoxycarbonyl)pyrrole-5-dithiocarboxylic acid was obtained in 10% yield from 2-methyl-3-(ethoxycarbonyl)pyrrole with AlCl3 and CS2. These reactions show CS2 was not an indifferent solvent in Friedel-Crafts reactions.

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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Halogen compounds of ferrocene》. Authors are Nesmeyanov, A. N.; Perevalova, E. G.; Nesmeyanova, O. A..The article about the compound:Bromoferrocenecas:1273-73-0,SMILESS:Br[C-]12[Fe+2]3456789([C-]%10C6=C7C8=C9%10)C1=C3C4=C25).Computed Properties of C10BrFe. Through the article, more information about this compound (cas:1273-73-0) is conveyed.

Iodine and ferrocene in organic medium yields a complex containing 20 atoms of iodine per mole of ferrocene, a black solid with green luster, decompose 170-2°; crystallization from Me2CO yields a complex with 6 atoms of iodine per mol., black, decompose 125-30°. The former complex in H2O yields the ferricinium cation color, while the latter complex is unattacked by H2O. Na2S2O3 removes iodine, from the complexes. Br and ferrocene give a brown complex, which is flammable when dry. Heating ferrocene with Br in CCl4 yields pentabromocyclopentane, m. 103-4°; Cl decomposes ferrocene at room temperature but at -30° in CHCl3 it yields a complex with 26% Cl. Ferrocenylmercury chloride in hot xylene treated with iodine gave a green precipitate of a complex of ferrocenylmercury chloride with 4 atoms of iodine; aqueous Na2S2O3 converts this to bisferrocenylmercury. Much iodine converts the complex and replaces Hg by iodine and the precipitate turns black, yielding 64% iodoferrocene after treatment with Na2S2O3. Iodoferrocene is yellow-orange, m. 44-5°, is volatile with steam and can be crystallized from MeOH at -10°. Its iodine is inert; heated to 100° it yields ferrocene and some C; it fails to form RMgI with Mg. Bisferrocenylmercury with excess Br in CHCl3 gave after 0.5 hr. refluxing, followed by treatment with Na2S2O3, a low yield of bromoferrocene, yellow, m. 30-1° (from MeOH). Treatment of bis(chloromercury)ferrocene with I or Br gave the corresponding diiodo- and dibromoferrocenes. The former, 25%, was not pure even after chromatographic purification; it was a red liquid, d20 2.286, d36 2.262, nD26 1.682. Dibromoferrocene, red liquid, absorption maximum 438 mμ. Bromoferrocene has an absolute maximum at 437; diiodoferrocene 438; iodoferrocene 435 mμ.

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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com